Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters
Abstract Lipase‐catalyzed synthesis of sugar fatty acid esters was performed in a heterogeneous reaction system in the presence of an organic solvent serving as adjuvant . Although the sugar is almost insoluble in such a system, high conversions to the corresponding sugar esters were achieved, due t...
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1996
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crwiley:10.1002/lipi.19960981003 2024-09-15T17:48:22+00:00 Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters Cao, Linqiu Bornscheuer, Uwe T. Schmid, Rolf D. 1996 http://dx.doi.org/10.1002/lipi.19960981003 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flipi.19960981003 https://onlinelibrary.wiley.com/doi/pdf/10.1002/lipi.19960981003 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Lipid / Fett volume 98, issue 10, page 332-335 ISSN 0931-5985 journal-article 1996 crwiley https://doi.org/10.1002/lipi.19960981003 2024-06-25T04:18:31Z Abstract Lipase‐catalyzed synthesis of sugar fatty acid esters was performed in a heterogeneous reaction system in the presence of an organic solvent serving as adjuvant . Although the sugar is almost insoluble in such a system, high conversions to the corresponding sugar esters were achieved, due to crystallization of the product. Acylation occurred regioselectively at the primary hydroxyl group and subsequent diacylation was observed only in the case of caprylic acid (2–5%). Best conditions were found for solvents having low log P values and low product solubility such as acetone, using immobilized lipase from Candida antarctica (CAL‐B, Novo SP435) and fatty acids with chain lengths from C 12 to C 8 as acyl donors. The esterification of β‐D(+)‐glucose with stearic acid resulted in up to 100% conversion after 48 hours equal to a productivity of 0.4 mmol sugar ester per gram lipase and hour. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Lipid / Fett 98 10 332 335 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Lipase‐catalyzed synthesis of sugar fatty acid esters was performed in a heterogeneous reaction system in the presence of an organic solvent serving as adjuvant . Although the sugar is almost insoluble in such a system, high conversions to the corresponding sugar esters were achieved, due to crystallization of the product. Acylation occurred regioselectively at the primary hydroxyl group and subsequent diacylation was observed only in the case of caprylic acid (2–5%). Best conditions were found for solvents having low log P values and low product solubility such as acetone, using immobilized lipase from Candida antarctica (CAL‐B, Novo SP435) and fatty acids with chain lengths from C 12 to C 8 as acyl donors. The esterification of β‐D(+)‐glucose with stearic acid resulted in up to 100% conversion after 48 hours equal to a productivity of 0.4 mmol sugar ester per gram lipase and hour. |
format |
Article in Journal/Newspaper |
author |
Cao, Linqiu Bornscheuer, Uwe T. Schmid, Rolf D. |
spellingShingle |
Cao, Linqiu Bornscheuer, Uwe T. Schmid, Rolf D. Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
author_facet |
Cao, Linqiu Bornscheuer, Uwe T. Schmid, Rolf D. |
author_sort |
Cao, Linqiu |
title |
Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
title_short |
Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
title_full |
Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
title_fullStr |
Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
title_full_unstemmed |
Lipase‐Catalyzed Solid Phase Synthesis of Sugar Esters |
title_sort |
lipase‐catalyzed solid phase synthesis of sugar esters |
publisher |
Wiley |
publishDate |
1996 |
url |
http://dx.doi.org/10.1002/lipi.19960981003 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flipi.19960981003 https://onlinelibrary.wiley.com/doi/pdf/10.1002/lipi.19960981003 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Lipid / Fett volume 98, issue 10, page 332-335 ISSN 0931-5985 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/lipi.19960981003 |
container_title |
Lipid / Fett |
container_volume |
98 |
container_issue |
10 |
container_start_page |
332 |
op_container_end_page |
335 |
_version_ |
1810289519977562112 |