Effects of long‐term intake of Antarctic krill oils on artery blood pressure in spontaneously hypertensive rats

• Published in: Journal of the Science of Food and Agriculture
• Main Authors: Zhou, Da‐Yong, Liu, Yu‐Xin, Xu, Zhi‐Li, Yin, Fa‐Wen, Song, Liang, Wan, Xiu‐Lin, Song, Yu‐Kun, Zhu, Bei‐Wei
• Other Authors: The National High Technology Research and Development Program of China (863 Program), Program for Liaoning Excellent Talents in University, Project of Distinguished Professor of Liaoning Province, Liaoning Provincial Natural Science Foundation of China, Program for Dalian High-Level Innovative Talent, Ministry of Science and Technology of the People's Republic of China
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: Antarc*; Antarctic; Antarctic Krill
• Online Access: http://dx.doi.org/10.1002/jsfa.7840; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjsfa.7840; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsfa.7840

Abstract BACKGROUND In recent years, there has been a noticeable increase in research on krill oil ( KO ) for its health benefits. However, the action of KO in lowering blood pressure ( BP ) has not been studied yet. Therefore the aim of this study was to assess the ability of long‐term KO supplementation to lower systolic BP ( SBP ) in spontaneously hypertensive rats ( SHRs ) and Sprague Dawley ( SD ) rats. RESULTS Compared with the blank control ( BC ) SHRs administered edible soybean oil, the high‐dose (500 mg kg −1 body weight ( BW )) KO ‐supplemented SHRs in the 2nd, 3rd, 4th and 5th weeks following oral administration, the mid‐dose (100 mg kg −1 BW ) KO ‐supplemented SHRs in the 4th and 5th weeks following oral administration and the low‐dose (20 mg kg −1 BW ) KO ‐supplemented SHRs in the 5th week following oral administration showed significantly lower SBP ( P < 0.05). However, supplementation of KO had no significant effect on the SBP of healthy SD rats. Meanwhile, 5 weeks of KO administration significantly increased the serum levels of nitric oxide ( NO ) and total NO synthase of SHRs ( P < 0.05). CONCLUSION KO has an antihypertensive effect in SHRs that is associated with an NO ‐related mechanism. © 2016 Society of Chemical Industry