Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment
Abstract BACKGROUND Dried and salt‐fermented fish products are important sources of N ‐nitrosodimethylamine (NDMA) exposure for human. As a potent carcinogen, NDMA was frequently detected in roasted Alaska pollock fillet products (RPFs), which is among the most common fish products in China. Until n...
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Online Access: | http://dx.doi.org/10.1002/jsfa.12786 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsfa.12786 |
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crwiley:10.1002/jsfa.12786 2024-06-23T07:45:03+00:00 Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment Sun, Yong Jiang, Bing Wang, Xiaoli Liu, Nan Yang, Min Wang, Shanshan Guo, Yingying Zhou, Deqing National Key Research and Development Program of China 2023 http://dx.doi.org/10.1002/jsfa.12786 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsfa.12786 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of the Science of Food and Agriculture volume 103, issue 14, page 6940-6946 ISSN 0022-5142 1097-0010 journal-article 2023 crwiley https://doi.org/10.1002/jsfa.12786 2024-06-13T04:21:09Z Abstract BACKGROUND Dried and salt‐fermented fish products are important sources of N ‐nitrosodimethylamine (NDMA) exposure for human. As a potent carcinogen, NDMA was frequently detected in roasted Alaska pollock fillet products (RPFs), which is among the most common fish products in China. Until now, the occurrence and development of NDMA and its precursors (nitrites, nitrates and dimethylamine) in RPFs during processing and storage were not well elucidated, and safety evaluation of this fish product is also urgently needed. RESULTS The presence of precursors in the raw material was verified and significant increase of nitrates and nitrites during processing was observed. NDMA was found generated during pre‐drying (3.7 μg kg −1 dry basis) and roasting (14.6 μg kg −1 dry basis) process. Continuous increase in NDMA content can also be found during storage, especially at higher storage temperature. The 95th percentile of Monte Carlo simulated cancer risk (3.73 × 10 −5 ) surpassed the WHO threshold (1.00 × 10 −5 ) and sensitivity analysis implies the risk was mainly attributable to NDMA level in RPFs. CONCLUSION The occurrence of NDMA in RFPs was mainly a result of endogenous factors originating in Alaska pollock during processing and storage rather than exogenous contamination, and temperature played a pivotal role. The preliminary risk assessment results suggest that long‐term consumption of RPFs would impose potential health risks for consumers. © 2023 Society of Chemical Industry. Article in Journal/Newspaper alaska pollock Alaska Wiley Online Library Journal of the Science of Food and Agriculture 103 14 6940 6946 |
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Wiley Online Library |
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English |
description |
Abstract BACKGROUND Dried and salt‐fermented fish products are important sources of N ‐nitrosodimethylamine (NDMA) exposure for human. As a potent carcinogen, NDMA was frequently detected in roasted Alaska pollock fillet products (RPFs), which is among the most common fish products in China. Until now, the occurrence and development of NDMA and its precursors (nitrites, nitrates and dimethylamine) in RPFs during processing and storage were not well elucidated, and safety evaluation of this fish product is also urgently needed. RESULTS The presence of precursors in the raw material was verified and significant increase of nitrates and nitrites during processing was observed. NDMA was found generated during pre‐drying (3.7 μg kg −1 dry basis) and roasting (14.6 μg kg −1 dry basis) process. Continuous increase in NDMA content can also be found during storage, especially at higher storage temperature. The 95th percentile of Monte Carlo simulated cancer risk (3.73 × 10 −5 ) surpassed the WHO threshold (1.00 × 10 −5 ) and sensitivity analysis implies the risk was mainly attributable to NDMA level in RPFs. CONCLUSION The occurrence of NDMA in RFPs was mainly a result of endogenous factors originating in Alaska pollock during processing and storage rather than exogenous contamination, and temperature played a pivotal role. The preliminary risk assessment results suggest that long‐term consumption of RPFs would impose potential health risks for consumers. © 2023 Society of Chemical Industry. |
author2 |
National Key Research and Development Program of China |
format |
Article in Journal/Newspaper |
author |
Sun, Yong Jiang, Bing Wang, Xiaoli Liu, Nan Yang, Min Wang, Shanshan Guo, Yingying Zhou, Deqing |
spellingShingle |
Sun, Yong Jiang, Bing Wang, Xiaoli Liu, Nan Yang, Min Wang, Shanshan Guo, Yingying Zhou, Deqing Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
author_facet |
Sun, Yong Jiang, Bing Wang, Xiaoli Liu, Nan Yang, Min Wang, Shanshan Guo, Yingying Zhou, Deqing |
author_sort |
Sun, Yong |
title |
Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
title_short |
Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
title_full |
Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
title_fullStr |
Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
title_full_unstemmed |
Occurrence of N‐nitrosodimethylamine in roasted Alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
title_sort |
occurrence of n‐nitrosodimethylamine in roasted alaska pollock fillets during processing and storage and preliminary cancer risk assessment |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1002/jsfa.12786 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsfa.12786 |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Journal of the Science of Food and Agriculture volume 103, issue 14, page 6940-6946 ISSN 0022-5142 1097-0010 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jsfa.12786 |
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Journal of the Science of Food and Agriculture |
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103 |
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14 |
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6940 |
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6946 |
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1802649442310946816 |