Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016
Abstract Background The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high‐sensitivity C‐reactive protein (hs‐CRP), and glycated...
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crwiley:10.1002/jper.23-0108 2024-06-02T08:15:20+00:00 Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler‐Olsen, Elin Vieira, Alexandre R. Petzold, Max Larsson, Lena 2023 http://dx.doi.org/10.1002/jper.23-0108 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Journal of Periodontology volume 94, issue 11, page 1324-1337 ISSN 0022-3492 1943-3670 journal-article 2023 crwiley https://doi.org/10.1002/jper.23-0108 2024-05-03T11:44:49Z Abstract Background The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high‐sensitivity C‐reactive protein (hs‐CRP), and glycated hemoglobin (HbA1c) levels. Methods We included participants with periodontal examination ( n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs ( rs2288349 , rs35474715 , rs34023346 , and rs10010325 ) in the sequence of the genes DNMT1 , IDH2 , TET1 , and TET2 . Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed. Results In participants aged 40‐49 years, homozygous carriage of minor A‐allele of rs2288349 ( DNMT1 ) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A‐allele of rs10010325 ( TET2 ) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G‐allele of rs35474715 ( IDH2 ) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A‐allele of TET2 was associated with hs‐CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028). Conclusions In this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low‐grade inflammation, and hyperglycemia. Article in Journal/Newspaper Tromsø Wiley Online Library Norway Tromsø Journal of Periodontology |
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Wiley Online Library |
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Abstract Background The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high‐sensitivity C‐reactive protein (hs‐CRP), and glycated hemoglobin (HbA1c) levels. Methods We included participants with periodontal examination ( n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs ( rs2288349 , rs35474715 , rs34023346 , and rs10010325 ) in the sequence of the genes DNMT1 , IDH2 , TET1 , and TET2 . Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed. Results In participants aged 40‐49 years, homozygous carriage of minor A‐allele of rs2288349 ( DNMT1 ) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A‐allele of rs10010325 ( TET2 ) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G‐allele of rs35474715 ( IDH2 ) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A‐allele of TET2 was associated with hs‐CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028). Conclusions In this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low‐grade inflammation, and hyperglycemia. |
format |
Article in Journal/Newspaper |
author |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler‐Olsen, Elin Vieira, Alexandre R. Petzold, Max Larsson, Lena |
spellingShingle |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler‐Olsen, Elin Vieira, Alexandre R. Petzold, Max Larsson, Lena Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
author_facet |
Asa'ad, Farah Petrenya, Natalia Jönsson, Birgitta Holde, Gro Eirin Oscarson, Nils Hadler‐Olsen, Elin Vieira, Alexandre R. Petzold, Max Larsson, Lena |
author_sort |
Asa'ad, Farah |
title |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
title_short |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
title_full |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
title_fullStr |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
title_full_unstemmed |
Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016 |
title_sort |
polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity c‐reactive protein and glycated hemoglobin: the tromsø study 2015‐2016 |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1002/jper.23-0108 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Journal of Periodontology volume 94, issue 11, page 1324-1337 ISSN 0022-3492 1943-3670 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1002/jper.23-0108 |
container_title |
Journal of Periodontology |
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1800739467389042688 |