Tissue fluid pressures: From basic research tools to clinical applications
Abstract The two basic research tools developed to measure tissue fluid pressure (wick catheter) and osmotic pressure (colloid osmometer) have undergone extensive validation and refinement over the past 20 years. Using these techniques, basic science investigations were undertaken of edema in Amazon...
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crwiley:10.1002/jor.1100070617 2024-06-09T07:39:31+00:00 Tissue fluid pressures: From basic research tools to clinical applications Hargens, Alan R. Akeson, Wayne H. Mubarak, Scott J. Owen, Charles A. Gershuni, David H. Garfin, Steven R. Lieber, Richard L. Danzig, Larry A. Botte, Michael J. Gelberman, Richard H. 1989 http://dx.doi.org/10.1002/jor.1100070617 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjor.1100070617 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.1100070617 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Orthopaedic Research volume 7, issue 6, page 902-909 ISSN 0736-0266 1554-527X journal-article 1989 crwiley https://doi.org/10.1002/jor.1100070617 2024-05-16T14:26:25Z Abstract The two basic research tools developed to measure tissue fluid pressure (wick catheter) and osmotic pressure (colloid osmometer) have undergone extensive validation and refinement over the past 20 years. Using these techniques, basic science investigations were undertaken of edema in Amazon reptiles, pressure‐volume relations in animals and plants, adaptive physiology of Antarctic penguins and fishes, edema in spawning salmon, tissue fluid balance in humans under normal conditions and during simulated weightlessness, and orthostatic adaptation in a mammal with high and variable blood pressures—the giraffe. Following and sometimes paralleling this basic research have been several clinical applications related to use of our colloid osmometer and wick technique. Applications of the osmometer have included insights into (a) reduced osmotic pressure of sickle‐cell hemoglobin with deoxygenation and (b) reduced swelling pressure of human nucleus pulposus with hydration or certain enzymes. Clinical uses of the wick technique have included (a) improvement of diagnosis and treatment of acute and chronic compartment syndromes, (b) elucidation of tissue pressure thresholds for neuromuscular dysfunction, and (c) development of a better tourniquet design for orthopaedics. This article demonstrates that basic research tools open up areas of basic, applied, and clinical research. Article in Journal/Newspaper Antarc* Antarctic Wiley Online Library Antarctic Sickle ENVELOPE(-66.783,-66.783,-68.867,-68.867) Journal of Orthopaedic Research 7 6 902 909 |
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Wiley Online Library |
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English |
description |
Abstract The two basic research tools developed to measure tissue fluid pressure (wick catheter) and osmotic pressure (colloid osmometer) have undergone extensive validation and refinement over the past 20 years. Using these techniques, basic science investigations were undertaken of edema in Amazon reptiles, pressure‐volume relations in animals and plants, adaptive physiology of Antarctic penguins and fishes, edema in spawning salmon, tissue fluid balance in humans under normal conditions and during simulated weightlessness, and orthostatic adaptation in a mammal with high and variable blood pressures—the giraffe. Following and sometimes paralleling this basic research have been several clinical applications related to use of our colloid osmometer and wick technique. Applications of the osmometer have included insights into (a) reduced osmotic pressure of sickle‐cell hemoglobin with deoxygenation and (b) reduced swelling pressure of human nucleus pulposus with hydration or certain enzymes. Clinical uses of the wick technique have included (a) improvement of diagnosis and treatment of acute and chronic compartment syndromes, (b) elucidation of tissue pressure thresholds for neuromuscular dysfunction, and (c) development of a better tourniquet design for orthopaedics. This article demonstrates that basic research tools open up areas of basic, applied, and clinical research. |
format |
Article in Journal/Newspaper |
author |
Hargens, Alan R. Akeson, Wayne H. Mubarak, Scott J. Owen, Charles A. Gershuni, David H. Garfin, Steven R. Lieber, Richard L. Danzig, Larry A. Botte, Michael J. Gelberman, Richard H. |
spellingShingle |
Hargens, Alan R. Akeson, Wayne H. Mubarak, Scott J. Owen, Charles A. Gershuni, David H. Garfin, Steven R. Lieber, Richard L. Danzig, Larry A. Botte, Michael J. Gelberman, Richard H. Tissue fluid pressures: From basic research tools to clinical applications |
author_facet |
Hargens, Alan R. Akeson, Wayne H. Mubarak, Scott J. Owen, Charles A. Gershuni, David H. Garfin, Steven R. Lieber, Richard L. Danzig, Larry A. Botte, Michael J. Gelberman, Richard H. |
author_sort |
Hargens, Alan R. |
title |
Tissue fluid pressures: From basic research tools to clinical applications |
title_short |
Tissue fluid pressures: From basic research tools to clinical applications |
title_full |
Tissue fluid pressures: From basic research tools to clinical applications |
title_fullStr |
Tissue fluid pressures: From basic research tools to clinical applications |
title_full_unstemmed |
Tissue fluid pressures: From basic research tools to clinical applications |
title_sort |
tissue fluid pressures: from basic research tools to clinical applications |
publisher |
Wiley |
publishDate |
1989 |
url |
http://dx.doi.org/10.1002/jor.1100070617 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjor.1100070617 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.1100070617 |
long_lat |
ENVELOPE(-66.783,-66.783,-68.867,-68.867) |
geographic |
Antarctic Sickle |
geographic_facet |
Antarctic Sickle |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Journal of Orthopaedic Research volume 7, issue 6, page 902-909 ISSN 0736-0266 1554-527X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jor.1100070617 |
container_title |
Journal of Orthopaedic Research |
container_volume |
7 |
container_issue |
6 |
container_start_page |
902 |
op_container_end_page |
909 |
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1801380023709466624 |