Transplacental transfer of RSV antibody in Australian First Nations infants
Abstract Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection hospitalisations in Aboriginal infants specifically those aged <6 months. Maternally derived RSV antibody (Ab) can protect against severe RSV disease in infancy. However, the efficiency of transpl...
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Online Access: | http://dx.doi.org/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.27383 |
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crwiley:10.1002/jmv.27383 2024-06-02T08:06:40+00:00 Transplacental transfer of RSV antibody in Australian First Nations infants Homaira, Nusrat Binks, Michael Walker, Gregory Larter, Natasha Clark, Katrina Campbell, Megan McHugh, Lisa Briggs, Nancy Nyiro, Joyce Stelzer‐Braid, Sacha Hu, Nan Macartney, Kristine Snelling, Tom Omer, Saad B. Rawlinson, William Andrews, Ross Jaffe, Adam 2021 http://dx.doi.org/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.27383 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Medical Virology volume 94, issue 2, page 782-786 ISSN 0146-6615 1096-9071 journal-article 2021 crwiley https://doi.org/10.1002/jmv.27383 2024-05-03T11:41:48Z Abstract Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection hospitalisations in Aboriginal infants specifically those aged <6 months. Maternally derived RSV antibody (Ab) can protect against severe RSV disease in infancy. However, the efficiency of transplacental transfer of maternal anti‐RSV Ab remains unknown in Aboriginal infants. We characterised RSV Ab in Australian First Nations mother‐infant pairs ( n = 78). We investigated impact of covariates including low birthweight, gestational age (GA), sex of the baby, maternal age and multiparity of the mother on cord to maternal anti‐RSV Ab titre ratio (CMTR) using multivariable logistic regression model. All ( n = 78) but one infant was born full term (median GA: 39 weeks, interquartile range: 38–40 weeks) and 56% were males. The mean log 2 RSV Ab titre was 10.7 ( SD ± 1.3) in maternal serum and 11.0 ( SD ± 1.3) in cord serum at birth; a ratio of 1.02 ( SD ± 0.06). One‐third of the pairs had a CMTR of <1 indicating impaired transfer. Almost 9% (7/78) of the term infants had cord RSV Ab levels below <log 2 9. Covariates showed no effect on CMTR. Further mechanistic research is needed to determine the significance of these findings on RSV disease in First Nations children. Article in Journal/Newspaper First Nations Wiley Online Library Journal of Medical Virology 94 2 782 786 |
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English |
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Abstract Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection hospitalisations in Aboriginal infants specifically those aged <6 months. Maternally derived RSV antibody (Ab) can protect against severe RSV disease in infancy. However, the efficiency of transplacental transfer of maternal anti‐RSV Ab remains unknown in Aboriginal infants. We characterised RSV Ab in Australian First Nations mother‐infant pairs ( n = 78). We investigated impact of covariates including low birthweight, gestational age (GA), sex of the baby, maternal age and multiparity of the mother on cord to maternal anti‐RSV Ab titre ratio (CMTR) using multivariable logistic regression model. All ( n = 78) but one infant was born full term (median GA: 39 weeks, interquartile range: 38–40 weeks) and 56% were males. The mean log 2 RSV Ab titre was 10.7 ( SD ± 1.3) in maternal serum and 11.0 ( SD ± 1.3) in cord serum at birth; a ratio of 1.02 ( SD ± 0.06). One‐third of the pairs had a CMTR of <1 indicating impaired transfer. Almost 9% (7/78) of the term infants had cord RSV Ab levels below <log 2 9. Covariates showed no effect on CMTR. Further mechanistic research is needed to determine the significance of these findings on RSV disease in First Nations children. |
format |
Article in Journal/Newspaper |
author |
Homaira, Nusrat Binks, Michael Walker, Gregory Larter, Natasha Clark, Katrina Campbell, Megan McHugh, Lisa Briggs, Nancy Nyiro, Joyce Stelzer‐Braid, Sacha Hu, Nan Macartney, Kristine Snelling, Tom Omer, Saad B. Rawlinson, William Andrews, Ross Jaffe, Adam |
spellingShingle |
Homaira, Nusrat Binks, Michael Walker, Gregory Larter, Natasha Clark, Katrina Campbell, Megan McHugh, Lisa Briggs, Nancy Nyiro, Joyce Stelzer‐Braid, Sacha Hu, Nan Macartney, Kristine Snelling, Tom Omer, Saad B. Rawlinson, William Andrews, Ross Jaffe, Adam Transplacental transfer of RSV antibody in Australian First Nations infants |
author_facet |
Homaira, Nusrat Binks, Michael Walker, Gregory Larter, Natasha Clark, Katrina Campbell, Megan McHugh, Lisa Briggs, Nancy Nyiro, Joyce Stelzer‐Braid, Sacha Hu, Nan Macartney, Kristine Snelling, Tom Omer, Saad B. Rawlinson, William Andrews, Ross Jaffe, Adam |
author_sort |
Homaira, Nusrat |
title |
Transplacental transfer of RSV antibody in Australian First Nations infants |
title_short |
Transplacental transfer of RSV antibody in Australian First Nations infants |
title_full |
Transplacental transfer of RSV antibody in Australian First Nations infants |
title_fullStr |
Transplacental transfer of RSV antibody in Australian First Nations infants |
title_full_unstemmed |
Transplacental transfer of RSV antibody in Australian First Nations infants |
title_sort |
transplacental transfer of rsv antibody in australian first nations infants |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27383 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.27383 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Journal of Medical Virology volume 94, issue 2, page 782-786 ISSN 0146-6615 1096-9071 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jmv.27383 |
container_title |
Journal of Medical Virology |
container_volume |
94 |
container_issue |
2 |
container_start_page |
782 |
op_container_end_page |
786 |
_version_ |
1800751628841648128 |