Viral respiratory infections in hospitalized and community control children in Alaska
Abstract Respiratory syncytial virus (RSV) in Alaska Native children from the Yukon Kuskokwim (YK) Delta is associated with a hospitalization rate five times higher than that reported for the general US child population. The role of other viral respiratory pathogens has not been studied in this popu...
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crwiley:10.1002/jmv.21790 2024-06-23T07:54:25+00:00 Viral respiratory infections in hospitalized and community control children in Alaska Singleton, Rosalyn J. Bulkow, Lisa R. Miernyk, Karen DeByle, Carolynn Pruitt, Lori Hummel, Kimberlee Boyd Bruden, Dana Englund, Janet A. Anderson, Larry J. Lucher, Lynne Holman, Robert C. Hennessy, Thomas W. 2010 http://dx.doi.org/10.1002/jmv.21790 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.21790 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.21790 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Medical Virology volume 82, issue 7, page 1282-1290 ISSN 0146-6615 1096-9071 journal-article 2010 crwiley https://doi.org/10.1002/jmv.21790 2024-06-06T04:20:21Z Abstract Respiratory syncytial virus (RSV) in Alaska Native children from the Yukon Kuskokwim (YK) Delta is associated with a hospitalization rate five times higher than that reported for the general US child population. The role of other viral respiratory pathogens has not been studied in this population. YK Delta children <3 years of age hospitalized with respiratory infections and same aged community control children were prospectively enrolled between October 2005 and September 2007. Polymerase chain reaction detection of viruses was performed on nasopharyngeal samples. Characteristics of hospitalized and asymptomatic control children were analyzed. From October 2005 to September 2007, 440 hospitalized and 425 control children were analyzed. Respiratory viruses were detected in 90% (395) of hospitalized children: 194 (44%) rhinovirus, 131 (30%) adenovirus, 102 (23%) RSV, 77 (18%) para influenza viruses (PIV), 66 (15%) human metapneumovirus (hMPV), 23 (5%) influenza, and 25 (6%) coronavirus. Fifty‐two percent (221) of control children had a virus detected, most commonly rhinovirus (33%), and adenovirus (16%). RSV, PIV, hMPV, and influenza were significantly more common in hospitalized cases than control children, but rhinovirus, adenovirus, and coronavirus were not. RSV and hMPV were associated with higher severity of illness. In this study, RSV remains the most important virus associated with respiratory hospitalization, although hMPV and PIV were also common. RSV and hMPV were associated with more severe illness. Rhinovirus and adenovirus were detected in two‐thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain. J. Med. Virol. 82:1282–1290, 2010. © 2010 Wiley‐Liss, Inc. Article in Journal/Newspaper Kuskokwim Alaska Yukon Wiley Online Library Yukon Journal of Medical Virology 82 7 1282 1290 |
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Wiley Online Library |
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English |
description |
Abstract Respiratory syncytial virus (RSV) in Alaska Native children from the Yukon Kuskokwim (YK) Delta is associated with a hospitalization rate five times higher than that reported for the general US child population. The role of other viral respiratory pathogens has not been studied in this population. YK Delta children <3 years of age hospitalized with respiratory infections and same aged community control children were prospectively enrolled between October 2005 and September 2007. Polymerase chain reaction detection of viruses was performed on nasopharyngeal samples. Characteristics of hospitalized and asymptomatic control children were analyzed. From October 2005 to September 2007, 440 hospitalized and 425 control children were analyzed. Respiratory viruses were detected in 90% (395) of hospitalized children: 194 (44%) rhinovirus, 131 (30%) adenovirus, 102 (23%) RSV, 77 (18%) para influenza viruses (PIV), 66 (15%) human metapneumovirus (hMPV), 23 (5%) influenza, and 25 (6%) coronavirus. Fifty‐two percent (221) of control children had a virus detected, most commonly rhinovirus (33%), and adenovirus (16%). RSV, PIV, hMPV, and influenza were significantly more common in hospitalized cases than control children, but rhinovirus, adenovirus, and coronavirus were not. RSV and hMPV were associated with higher severity of illness. In this study, RSV remains the most important virus associated with respiratory hospitalization, although hMPV and PIV were also common. RSV and hMPV were associated with more severe illness. Rhinovirus and adenovirus were detected in two‐thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain. J. Med. Virol. 82:1282–1290, 2010. © 2010 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Singleton, Rosalyn J. Bulkow, Lisa R. Miernyk, Karen DeByle, Carolynn Pruitt, Lori Hummel, Kimberlee Boyd Bruden, Dana Englund, Janet A. Anderson, Larry J. Lucher, Lynne Holman, Robert C. Hennessy, Thomas W. |
spellingShingle |
Singleton, Rosalyn J. Bulkow, Lisa R. Miernyk, Karen DeByle, Carolynn Pruitt, Lori Hummel, Kimberlee Boyd Bruden, Dana Englund, Janet A. Anderson, Larry J. Lucher, Lynne Holman, Robert C. Hennessy, Thomas W. Viral respiratory infections in hospitalized and community control children in Alaska |
author_facet |
Singleton, Rosalyn J. Bulkow, Lisa R. Miernyk, Karen DeByle, Carolynn Pruitt, Lori Hummel, Kimberlee Boyd Bruden, Dana Englund, Janet A. Anderson, Larry J. Lucher, Lynne Holman, Robert C. Hennessy, Thomas W. |
author_sort |
Singleton, Rosalyn J. |
title |
Viral respiratory infections in hospitalized and community control children in Alaska |
title_short |
Viral respiratory infections in hospitalized and community control children in Alaska |
title_full |
Viral respiratory infections in hospitalized and community control children in Alaska |
title_fullStr |
Viral respiratory infections in hospitalized and community control children in Alaska |
title_full_unstemmed |
Viral respiratory infections in hospitalized and community control children in Alaska |
title_sort |
viral respiratory infections in hospitalized and community control children in alaska |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1002/jmv.21790 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.21790 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.21790 |
geographic |
Yukon |
geographic_facet |
Yukon |
genre |
Kuskokwim Alaska Yukon |
genre_facet |
Kuskokwim Alaska Yukon |
op_source |
Journal of Medical Virology volume 82, issue 7, page 1282-1290 ISSN 0146-6615 1096-9071 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jmv.21790 |
container_title |
Journal of Medical Virology |
container_volume |
82 |
container_issue |
7 |
container_start_page |
1282 |
op_container_end_page |
1290 |
_version_ |
1802646574911717376 |