MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus
Abstract The immune system of marine mammals is of comparative interest because of its adaptation to the aquatic environment. Little information, however, is available on its cellular and molecular components. Here, we used a cross‐reactive antibody to MHC class II molecules and an immunoglobulin‐sp...
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crwiley:10.1002/jez.1402630110 2024-06-23T07:57:12+00:00 MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus Romano, Tracy A. Ridgway, Sam H. Quaranta, Vito 1992 http://dx.doi.org/10.1002/jez.1402630110 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402630110 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402630110 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Experimental Zoology volume 263, issue 1, page 96-104 ISSN 0022-104X 1097-010X journal-article 1992 crwiley https://doi.org/10.1002/jez.1402630110 2024-06-11T04:47:42Z Abstract The immune system of marine mammals is of comparative interest because of its adaptation to the aquatic environment. Little information, however, is available on its cellular and molecular components. Here, we used a cross‐reactive antibody to MHC class II molecules and an immunoglobulin‐specific antiserum for identifying these molecular species on lymphocytes of the bottlenosed dolphin, Tursiops truncatus . Limited structural analyses indicated that class II molecules and immunoglobulins of dolphin closely resemble those of other vertebrates. In the peripheral blood of most land mammals both class II and immunoglobulins are usually found on B but not T lymphocytes. Expression of immunoglobulins on dolphin peripheral blood lymphocytes suggests a ratio of B cells to T cells comparable to that of land mammals. However, unlike the majority of land mammals, virtually 100% of the peripheral T cells display pronounced expression of class II molecules, generally considered an indication of T cell activation. It is therefore possible that the physiology of T cell activation has unusual attributes in the dolphin. It is especially interesting that some land mammals, namely swine (ungulates) and dogs and cats (carnivores), also express class II molecules on peripheral blood T lymphocytes. Since ungulates and carnivores are thought to share a common distant ancestry with toothed whales, the evolutionary history may be more relevant than the environmental history in determining these unusual attributes. © 1992 Wiley‐Liss, Inc. Article in Journal/Newspaper toothed whales Wiley Online Library Journal of Experimental Zoology 263 1 96 104 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The immune system of marine mammals is of comparative interest because of its adaptation to the aquatic environment. Little information, however, is available on its cellular and molecular components. Here, we used a cross‐reactive antibody to MHC class II molecules and an immunoglobulin‐specific antiserum for identifying these molecular species on lymphocytes of the bottlenosed dolphin, Tursiops truncatus . Limited structural analyses indicated that class II molecules and immunoglobulins of dolphin closely resemble those of other vertebrates. In the peripheral blood of most land mammals both class II and immunoglobulins are usually found on B but not T lymphocytes. Expression of immunoglobulins on dolphin peripheral blood lymphocytes suggests a ratio of B cells to T cells comparable to that of land mammals. However, unlike the majority of land mammals, virtually 100% of the peripheral T cells display pronounced expression of class II molecules, generally considered an indication of T cell activation. It is therefore possible that the physiology of T cell activation has unusual attributes in the dolphin. It is especially interesting that some land mammals, namely swine (ungulates) and dogs and cats (carnivores), also express class II molecules on peripheral blood T lymphocytes. Since ungulates and carnivores are thought to share a common distant ancestry with toothed whales, the evolutionary history may be more relevant than the environmental history in determining these unusual attributes. © 1992 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Romano, Tracy A. Ridgway, Sam H. Quaranta, Vito |
spellingShingle |
Romano, Tracy A. Ridgway, Sam H. Quaranta, Vito MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
author_facet |
Romano, Tracy A. Ridgway, Sam H. Quaranta, Vito |
author_sort |
Romano, Tracy A. |
title |
MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
title_short |
MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
title_full |
MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
title_fullStr |
MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
title_full_unstemmed |
MHC class II molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, Tursiops truncatus |
title_sort |
mhc class ii molecules and immunoglobulins on peripheral blood lymphocytes of the bottlenosed dolphin, tursiops truncatus |
publisher |
Wiley |
publishDate |
1992 |
url |
http://dx.doi.org/10.1002/jez.1402630110 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402630110 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402630110 |
genre |
toothed whales |
genre_facet |
toothed whales |
op_source |
Journal of Experimental Zoology volume 263, issue 1, page 96-104 ISSN 0022-104X 1097-010X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jez.1402630110 |
container_title |
Journal of Experimental Zoology |
container_volume |
263 |
container_issue |
1 |
container_start_page |
96 |
op_container_end_page |
104 |
_version_ |
1802650719230099456 |