Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias
Abstract Angiotensin II was infused intravenously in spiny dogfish sharks ( Squalus acanthias ). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre‐ and postinfusion values or in comparison with values m...
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crwiley:10.1002/jez.1402340104 2024-09-15T18:41:56+00:00 Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias Churchill, Paul C. Malvin, Richard L. Churchill, Monique C. 1985 http://dx.doi.org/10.1002/jez.1402340104 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402340104 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402340104 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Experimental Zoology volume 234, issue 1, page 17-22 ISSN 0022-104X 1097-010X journal-article 1985 crwiley https://doi.org/10.1002/jez.1402340104 2024-08-01T04:21:44Z Abstract Angiotensin II was infused intravenously in spiny dogfish sharks ( Squalus acanthias ). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre‐ and postinfusion values or in comparison with values measured in a control group of fish given elasmobranch saline intravenously. In other dogfish, glomerular filtration rate, urine flow, and Na and K excretory rates were measured for 3 days following implantation of desoxycorticosterone (DOCA), adrenocorticotropin (ACTH), or spironolactone; a control group was given no drug. There were no significant differences between these four groups of fish with respect to any of the measured parameters. These results suggest that the dogfish kidney is not a target organ for several substances known to affect renal function, either directly or indirectly, in other animals. Article in Journal/Newspaper spiny dogfish Squalus acanthias Wiley Online Library Journal of Experimental Zoology 234 1 17 22 |
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Wiley Online Library |
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language |
English |
description |
Abstract Angiotensin II was infused intravenously in spiny dogfish sharks ( Squalus acanthias ). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre‐ and postinfusion values or in comparison with values measured in a control group of fish given elasmobranch saline intravenously. In other dogfish, glomerular filtration rate, urine flow, and Na and K excretory rates were measured for 3 days following implantation of desoxycorticosterone (DOCA), adrenocorticotropin (ACTH), or spironolactone; a control group was given no drug. There were no significant differences between these four groups of fish with respect to any of the measured parameters. These results suggest that the dogfish kidney is not a target organ for several substances known to affect renal function, either directly or indirectly, in other animals. |
format |
Article in Journal/Newspaper |
author |
Churchill, Paul C. Malvin, Richard L. Churchill, Monique C. |
spellingShingle |
Churchill, Paul C. Malvin, Richard L. Churchill, Monique C. Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
author_facet |
Churchill, Paul C. Malvin, Richard L. Churchill, Monique C. |
author_sort |
Churchill, Paul C. |
title |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
title_short |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
title_full |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
title_fullStr |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
title_full_unstemmed |
Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias |
title_sort |
lack of renal effects of doca, acth, spironolactone, and angiotensin ii in squalus acanthias |
publisher |
Wiley |
publishDate |
1985 |
url |
http://dx.doi.org/10.1002/jez.1402340104 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402340104 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402340104 |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_source |
Journal of Experimental Zoology volume 234, issue 1, page 17-22 ISSN 0022-104X 1097-010X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jez.1402340104 |
container_title |
Journal of Experimental Zoology |
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234 |
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1 |
container_start_page |
17 |
op_container_end_page |
22 |
_version_ |
1810486302612652032 |