Lack of renal effects of DOCA, ACTH, spironolactone, and angiotensin II in Squalus acanthias
Abstract Angiotensin II was infused intravenously in spiny dogfish sharks ( Squalus acanthias ). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre‐ and postinfusion values or in comparison with values m...
| Published in: | Journal of Experimental Zoology |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wiley
1985
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1002/jez.1402340104 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402340104 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402340104 |
| Summary: | Abstract Angiotensin II was infused intravenously in spiny dogfish sharks ( Squalus acanthias ). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre‐ and postinfusion values or in comparison with values measured in a control group of fish given elasmobranch saline intravenously. In other dogfish, glomerular filtration rate, urine flow, and Na and K excretory rates were measured for 3 days following implantation of desoxycorticosterone (DOCA), adrenocorticotropin (ACTH), or spironolactone; a control group was given no drug. There were no significant differences between these four groups of fish with respect to any of the measured parameters. These results suggest that the dogfish kidney is not a target organ for several substances known to affect renal function, either directly or indirectly, in other animals. |
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