Model validation for enzymatic reactive distillation to produce chiral compounds
Abstract BACKGROUND Enzymatic reactive distillation (ERD) is a biocatalyzed process, in which enzymes are immobilized in catalytic packing. The combination of enzymatic reaction and thermal separation helps to overcome chemical reaction and phase equilibrium limitations. Processing of chiral molecul...
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crwiley:10.1002/jctb.5380 2024-06-02T07:58:09+00:00 Model validation for enzymatic reactive distillation to produce chiral compounds Wierschem, Matthias Langen, Anke Alexandra Lins, Janine Spitzer, Rüdiger Skiborowski, Mirko Ministry of Innovation, Science and Research of North Rhine-Westphalia in the framework of CLIB-Graduate Cluster Industrial Biotechnology 2017 http://dx.doi.org/10.1002/jctb.5380 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjctb.5380 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jctb.5380 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Chemical Technology & Biotechnology volume 93, issue 2, page 498-507 ISSN 0268-2575 1097-4660 journal-article 2017 crwiley https://doi.org/10.1002/jctb.5380 2024-05-03T11:22:55Z Abstract BACKGROUND Enzymatic reactive distillation (ERD) is a biocatalyzed process, in which enzymes are immobilized in catalytic packing. The combination of enzymatic reaction and thermal separation helps to overcome chemical reaction and phase equilibrium limitations. Processing of chiral molecules, in particular, can benefit from ERD application, which might lead to more eco‐efficient processing of these valuable chemicals. Therefore an integrated approach to evaluate this technology is followed. RESULTS To evaluate ERD the transesterification of racemic (R/S)‐1‐phenylethanol (RPE/SPE) to (R)‐phenylethyl acetate (PEA) catalyzed by Candida antarctica lipase B (EC: 3.1.1.3) is investigated with regard to kinetics and physical property data, which provide a basis for the modeling of an ERD process. Furthermore, ERD experiments show a selective conversion of RPE to PEA, which is predicted by the established ERD model with high accuracy. CONCLUSION The ERD experiments demonstrate the feasibility of chiral processing for the transesterification by means of ERD and a validated ERD model is developed, allowing for a conceptual evaluation of ERD. This provides the basis for a future comparison of ERD with benchmark processes that will reveal the economic potential of ERD processes. © 2017 Society of Chemical Industry Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Journal of Chemical Technology & Biotechnology 93 2 498 507 |
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Wiley Online Library |
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English |
description |
Abstract BACKGROUND Enzymatic reactive distillation (ERD) is a biocatalyzed process, in which enzymes are immobilized in catalytic packing. The combination of enzymatic reaction and thermal separation helps to overcome chemical reaction and phase equilibrium limitations. Processing of chiral molecules, in particular, can benefit from ERD application, which might lead to more eco‐efficient processing of these valuable chemicals. Therefore an integrated approach to evaluate this technology is followed. RESULTS To evaluate ERD the transesterification of racemic (R/S)‐1‐phenylethanol (RPE/SPE) to (R)‐phenylethyl acetate (PEA) catalyzed by Candida antarctica lipase B (EC: 3.1.1.3) is investigated with regard to kinetics and physical property data, which provide a basis for the modeling of an ERD process. Furthermore, ERD experiments show a selective conversion of RPE to PEA, which is predicted by the established ERD model with high accuracy. CONCLUSION The ERD experiments demonstrate the feasibility of chiral processing for the transesterification by means of ERD and a validated ERD model is developed, allowing for a conceptual evaluation of ERD. This provides the basis for a future comparison of ERD with benchmark processes that will reveal the economic potential of ERD processes. © 2017 Society of Chemical Industry |
author2 |
Ministry of Innovation, Science and Research of North Rhine-Westphalia in the framework of CLIB-Graduate Cluster Industrial Biotechnology |
format |
Article in Journal/Newspaper |
author |
Wierschem, Matthias Langen, Anke Alexandra Lins, Janine Spitzer, Rüdiger Skiborowski, Mirko |
spellingShingle |
Wierschem, Matthias Langen, Anke Alexandra Lins, Janine Spitzer, Rüdiger Skiborowski, Mirko Model validation for enzymatic reactive distillation to produce chiral compounds |
author_facet |
Wierschem, Matthias Langen, Anke Alexandra Lins, Janine Spitzer, Rüdiger Skiborowski, Mirko |
author_sort |
Wierschem, Matthias |
title |
Model validation for enzymatic reactive distillation to produce chiral compounds |
title_short |
Model validation for enzymatic reactive distillation to produce chiral compounds |
title_full |
Model validation for enzymatic reactive distillation to produce chiral compounds |
title_fullStr |
Model validation for enzymatic reactive distillation to produce chiral compounds |
title_full_unstemmed |
Model validation for enzymatic reactive distillation to produce chiral compounds |
title_sort |
model validation for enzymatic reactive distillation to produce chiral compounds |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1002/jctb.5380 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjctb.5380 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jctb.5380 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Journal of Chemical Technology & Biotechnology volume 93, issue 2, page 498-507 ISSN 0268-2575 1097-4660 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jctb.5380 |
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Journal of Chemical Technology & Biotechnology |
container_volume |
93 |
container_issue |
2 |
container_start_page |
498 |
op_container_end_page |
507 |
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1800741437325705216 |