Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid
Abstract Isoniazid is a useful antitubercular drug widely employed in combination therapy with rifampicin. The synthesis of isoniazid from ethyl isonicotinate and hydrazine hydrate was studied in non‐aqueous media via lipase‐catalyzed hydrazinolysis under both conventional heating and microwave irra...
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crwiley:10.1002/jctb.1738 2024-06-02T07:58:26+00:00 Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid Yadav, Ganapati D Sajgure, Ashwini D 2007 http://dx.doi.org/10.1002/jctb.1738 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjctb.1738 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jctb.1738 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Chemical Technology & Biotechnology volume 82, issue 11, page 964-970 ISSN 0268-2575 1097-4660 journal-article 2007 crwiley https://doi.org/10.1002/jctb.1738 2024-05-03T11:54:16Z Abstract Isoniazid is a useful antitubercular drug widely employed in combination therapy with rifampicin. The synthesis of isoniazid from ethyl isonicotinate and hydrazine hydrate was studied in non‐aqueous media via lipase‐catalyzed hydrazinolysis under both conventional heating and microwave irradiation by using different supported lipases. Among three different commercial lipases used, namely Novozym 435 ( Candida antarctica lipase), Lipozyme RM IM ( Rhizomucor miehei lipase) and Lipozyme TL IM ( Thermomyces lanuginosus lipase), Novozym 435 was found to be the most effective, with conversion of 54% for equimolar concentrations at 50 °C in 4 h. The rate of reaction as well as final conversion increased synergistically under microwave irradiation in comparison with conventional heating, which showed 36.4% conversion, even after 24 h, for the control experiment. Effects of various process parameters such as speed of agitation, catalyst loading, substrate concentration, product concentration and temperature were studied. A kinetic model is also described. Copyright © 2007 Society of Chemical Industry Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Journal of Chemical Technology & Biotechnology 82 11 964 970 |
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English |
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Abstract Isoniazid is a useful antitubercular drug widely employed in combination therapy with rifampicin. The synthesis of isoniazid from ethyl isonicotinate and hydrazine hydrate was studied in non‐aqueous media via lipase‐catalyzed hydrazinolysis under both conventional heating and microwave irradiation by using different supported lipases. Among three different commercial lipases used, namely Novozym 435 ( Candida antarctica lipase), Lipozyme RM IM ( Rhizomucor miehei lipase) and Lipozyme TL IM ( Thermomyces lanuginosus lipase), Novozym 435 was found to be the most effective, with conversion of 54% for equimolar concentrations at 50 °C in 4 h. The rate of reaction as well as final conversion increased synergistically under microwave irradiation in comparison with conventional heating, which showed 36.4% conversion, even after 24 h, for the control experiment. Effects of various process parameters such as speed of agitation, catalyst loading, substrate concentration, product concentration and temperature were studied. A kinetic model is also described. Copyright © 2007 Society of Chemical Industry |
format |
Article in Journal/Newspaper |
author |
Yadav, Ganapati D Sajgure, Ashwini D |
spellingShingle |
Yadav, Ganapati D Sajgure, Ashwini D Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
author_facet |
Yadav, Ganapati D Sajgure, Ashwini D |
author_sort |
Yadav, Ganapati D |
title |
Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
title_short |
Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
title_full |
Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
title_fullStr |
Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
title_full_unstemmed |
Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
title_sort |
synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1002/jctb.1738 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjctb.1738 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jctb.1738 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Journal of Chemical Technology & Biotechnology volume 82, issue 11, page 964-970 ISSN 0268-2575 1097-4660 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jctb.1738 |
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Journal of Chemical Technology & Biotechnology |
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82 |
container_issue |
11 |
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964 |
op_container_end_page |
970 |
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1800741769116123136 |