New phomalone derivatives from the endolichenic fungus Cochliobolus kusanoi in Ny‐Alesund Arctic

• Published in: Journal of the Chinese Chemical Society
• Main Authors: Yang, Cailing, Xiao, Shiji, Yan, Song, Zhang, Maosheng, Cai, Qing, Fu, Shaobin, Meng, Qingfeng
• Other Authors: Guizhou Science and Technology Department
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2018
• Subjects: Arctic
• Online Access: http://dx.doi.org/10.1002/jccs.201800220; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjccs.201800220; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jccs.201800220

Natural products from endolichenic fungi, isolated from different lichen species, have been attracting much attention because of their potential to produce metabolites with activities and/or new structures. The filamentous fungus M227‐2 isolated from lichen in Ny‐Alesund Arctic showed significant anti‐microbial activity and was identified as Cochliobolus kusanoi based on 18S rDNA. Secondary metabolites of M227‐2 were investigated in order to exploit them as lead compounds for new antibiotics. Chemical investigation on M227‐2 led to the isolation of three phomalone derivatives (products 1 – 3) . Their structures were elucidated on the basis of their NMR and MS spectral data. Product 2 was new, whereas products 1 and 3 were isolated for the first time from the species. The biosynthetic pathway is also proposed.