Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil
Abstract Administration of a Prudhoe Bay crude oil (PBCO) to rats has been shown to (a) inhibit platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid, or epinephrine and (b) induce benzo‐α‐pyrene hydroxylase (BPH) in the liver and small intestine. Maximum inhibition of aggreg...
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crwiley:10.1002/jbt.2570020203 2024-06-02T08:13:33+00:00 Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil Chaudhury, Shibani Martin, Marie Payne, Jeremiah F. Rahimtula, Anver 1987 http://dx.doi.org/10.1002/jbt.2570020203 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbt.2570020203 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.2570020203 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Biochemical Toxicology volume 2, issue 2, page 93-104 ISSN 0887-2082 1522-7146 journal-article 1987 crwiley https://doi.org/10.1002/jbt.2570020203 2024-05-03T11:21:43Z Abstract Administration of a Prudhoe Bay crude oil (PBCO) to rats has been shown to (a) inhibit platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid, or epinephrine and (b) induce benzo‐α‐pyrene hydroxylase (BPH) in the liver and small intestine. Maximum inhibition of aggregation (90%) was seen 12 to 16 hours subsequent to dosing. However, substantial inhibition was observed as early as four hours and as late as 48 hours after dosing. Of particular interest was the sensitivity of the platelet response compared with the putatively sensitive response of monooxygenase induction in liver. As little as 0.1 ml of PBCO per kilogram body weight (bw) caused an inhibition of aggregation with all three agonists. A similar inhibition of the release of ADP from platelets in the presence of arachidonic acid or epinephrine was also observed. In contrast, hepatic BPH activity showed only a modest increase (67%) over the control value even after administration of 2 ml of PBCO per kilogram body weight. Small intestine BPH activity was more sensitive, showing a gradual increase of up to 19‐fold 24 hours after dosing with 2 ml of PBCO per kilogram body weight. The sensitivity of the platelet response is of general environmental interest and evaluating platelet aggregation in humans may be important as a noninvasive assay for exposure to either accidental or “acceptable” levels of petroleum hydrocarbons in the occupational environment. Article in Journal/Newspaper Prudhoe Bay Wiley Online Library Journal of Biochemical Toxicology 2 2 93 104 |
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English |
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Abstract Administration of a Prudhoe Bay crude oil (PBCO) to rats has been shown to (a) inhibit platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid, or epinephrine and (b) induce benzo‐α‐pyrene hydroxylase (BPH) in the liver and small intestine. Maximum inhibition of aggregation (90%) was seen 12 to 16 hours subsequent to dosing. However, substantial inhibition was observed as early as four hours and as late as 48 hours after dosing. Of particular interest was the sensitivity of the platelet response compared with the putatively sensitive response of monooxygenase induction in liver. As little as 0.1 ml of PBCO per kilogram body weight (bw) caused an inhibition of aggregation with all three agonists. A similar inhibition of the release of ADP from platelets in the presence of arachidonic acid or epinephrine was also observed. In contrast, hepatic BPH activity showed only a modest increase (67%) over the control value even after administration of 2 ml of PBCO per kilogram body weight. Small intestine BPH activity was more sensitive, showing a gradual increase of up to 19‐fold 24 hours after dosing with 2 ml of PBCO per kilogram body weight. The sensitivity of the platelet response is of general environmental interest and evaluating platelet aggregation in humans may be important as a noninvasive assay for exposure to either accidental or “acceptable” levels of petroleum hydrocarbons in the occupational environment. |
format |
Article in Journal/Newspaper |
author |
Chaudhury, Shibani Martin, Marie Payne, Jeremiah F. Rahimtula, Anver |
spellingShingle |
Chaudhury, Shibani Martin, Marie Payne, Jeremiah F. Rahimtula, Anver Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
author_facet |
Chaudhury, Shibani Martin, Marie Payne, Jeremiah F. Rahimtula, Anver |
author_sort |
Chaudhury, Shibani |
title |
Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
title_short |
Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
title_full |
Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
title_fullStr |
Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
title_full_unstemmed |
Alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
title_sort |
alterations in platelet aggregation and microsomal benzo‐α‐pyrene hydroxylase activities after exposure of rats to a prudhoe bay crude oil |
publisher |
Wiley |
publishDate |
1987 |
url |
http://dx.doi.org/10.1002/jbt.2570020203 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbt.2570020203 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.2570020203 |
genre |
Prudhoe Bay |
genre_facet |
Prudhoe Bay |
op_source |
Journal of Biochemical Toxicology volume 2, issue 2, page 93-104 ISSN 0887-2082 1522-7146 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jbt.2570020203 |
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Journal of Biochemical Toxicology |
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2 |
container_issue |
2 |
container_start_page |
93 |
op_container_end_page |
104 |
_version_ |
1800737098719821824 |