Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil
Abstract Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in an abrupt drop in liver mitochondrial and microsomal ATP‐dependent calcium uptake activity. Also, in vitro incubations of either mitochondria or microsomes in the presence of a dimethyl sulfoxide (DMSO) extract of PBCO resul...
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crwiley:10.1002/jbt.2570010404 2024-06-02T08:13:33+00:00 Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil Khan, S. Payne, J. F. Rahimtula, A. D. 1986 http://dx.doi.org/10.1002/jbt.2570010404 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbt.2570010404 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.2570010404 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Biochemical Toxicology volume 1, issue 4, page 31-43 ISSN 0887-2082 1522-7146 journal-article 1986 crwiley https://doi.org/10.1002/jbt.2570010404 2024-05-03T11:38:41Z Abstract Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in an abrupt drop in liver mitochondrial and microsomal ATP‐dependent calcium uptake activity. Also, in vitro incubations of either mitochondria or microsomes in the presence of a dimethyl sulfoxide (DMSO) extract of PBCO resulted in a dose‐dependent inhibition of calcium influx. The release of calcium from calciumloaded mitochondria and microsomes was also observed in the presence of the PBCO extract. At concentrations which effect calcium sequestration, the PBCO extract produced swelling of mitochondria. Microsomal ATPase activity in the presence or absence of calcium was unaffected by PBCO. The results indicate that increased permeability of the membranes to calcium is a contributory factor in the inhibition of calcium uptake by PBCO. Article in Journal/Newspaper Prudhoe Bay Wiley Online Library Journal of Biochemical Toxicology 1 4 31 43 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in an abrupt drop in liver mitochondrial and microsomal ATP‐dependent calcium uptake activity. Also, in vitro incubations of either mitochondria or microsomes in the presence of a dimethyl sulfoxide (DMSO) extract of PBCO resulted in a dose‐dependent inhibition of calcium influx. The release of calcium from calciumloaded mitochondria and microsomes was also observed in the presence of the PBCO extract. At concentrations which effect calcium sequestration, the PBCO extract produced swelling of mitochondria. Microsomal ATPase activity in the presence or absence of calcium was unaffected by PBCO. The results indicate that increased permeability of the membranes to calcium is a contributory factor in the inhibition of calcium uptake by PBCO. |
format |
Article in Journal/Newspaper |
author |
Khan, S. Payne, J. F. Rahimtula, A. D. |
spellingShingle |
Khan, S. Payne, J. F. Rahimtula, A. D. Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
author_facet |
Khan, S. Payne, J. F. Rahimtula, A. D. |
author_sort |
Khan, S. |
title |
Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
title_short |
Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
title_full |
Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
title_fullStr |
Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
title_full_unstemmed |
Mechanisms of petroleum hydrocarbon toxicity: Destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
title_sort |
mechanisms of petroleum hydrocarbon toxicity: destruction of liver microsomal and mitochondrial calcium pump activities by a prudhoe bay crude oil |
publisher |
Wiley |
publishDate |
1986 |
url |
http://dx.doi.org/10.1002/jbt.2570010404 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbt.2570010404 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.2570010404 |
genre |
Prudhoe Bay |
genre_facet |
Prudhoe Bay |
op_source |
Journal of Biochemical Toxicology volume 1, issue 4, page 31-43 ISSN 0887-2082 1522-7146 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jbt.2570010404 |
container_title |
Journal of Biochemical Toxicology |
container_volume |
1 |
container_issue |
4 |
container_start_page |
31 |
op_container_end_page |
43 |
_version_ |
1800737098100113408 |