Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections
Abstract Type‐A aortic dissection is an acute injury involving the delamination of the aorta at the parts of the aortic media. Aldehyde crosslinker‐containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the...
Published in: | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
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Online Access: | http://dx.doi.org/10.1002/jbm.b.35361 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.35361 |
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crwiley:10.1002/jbm.b.35361 2024-06-02T07:54:26+00:00 Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections Ito, Temmei Mizuta, Ryo Ito, Shima Taguchi, Tetsushi Uehara Memorial Foundation Japan Society for the Promotion of Science 2024 http://dx.doi.org/10.1002/jbm.b.35361 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.35361 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Biomedical Materials Research Part B: Applied Biomaterials volume 112, issue 1 ISSN 1552-4973 1552-4981 journal-article 2024 crwiley https://doi.org/10.1002/jbm.b.35361 2024-05-03T10:50:24Z Abstract Type‐A aortic dissection is an acute injury involving the delamination of the aorta at the parts of the aortic media. Aldehyde crosslinker‐containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the aortic media; however, they show low biocompatibility due to the release of aldehyde compounds. In this study, we report innovative adhesives based on hydrophobically modified Alaska pollock gelatin (hm‐ApGltn) with different alkyl or cholesteryl (Chol) groups that adhere to the media of the dissected aorta by combining hm‐ApGltns with a biocompatible crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The modification of alkyl or Chol groups contributed to enhanced adhesion strength between porcine aortic media. The adhesion strength increased with increasing modification ratios of alkyl groups from propanoyl to dodecanoyl groups and then decreased at a modification ratio of ~20 mol %. Porcine aortic media adhered using 7.5Chol‐ApGltn adhesive showed stretchability even when expanded and shrunk vertically by 25% at least five times. Hm‐ApGltn adhesives subcutaneously injected into the backs of mice showed no severe inflammation and were degraded during the implantation period. These results indicated that hm‐ApGltn adhesives have potential applications in type‐A aortic dissection. Article in Journal/Newspaper alaska pollock Alaska Wiley Online Library Journal of Biomedical Materials Research Part B: Applied Biomaterials 112 1 |
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Wiley Online Library |
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English |
description |
Abstract Type‐A aortic dissection is an acute injury involving the delamination of the aorta at the parts of the aortic media. Aldehyde crosslinker‐containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the aortic media; however, they show low biocompatibility due to the release of aldehyde compounds. In this study, we report innovative adhesives based on hydrophobically modified Alaska pollock gelatin (hm‐ApGltn) with different alkyl or cholesteryl (Chol) groups that adhere to the media of the dissected aorta by combining hm‐ApGltns with a biocompatible crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The modification of alkyl or Chol groups contributed to enhanced adhesion strength between porcine aortic media. The adhesion strength increased with increasing modification ratios of alkyl groups from propanoyl to dodecanoyl groups and then decreased at a modification ratio of ~20 mol %. Porcine aortic media adhered using 7.5Chol‐ApGltn adhesive showed stretchability even when expanded and shrunk vertically by 25% at least five times. Hm‐ApGltn adhesives subcutaneously injected into the backs of mice showed no severe inflammation and were degraded during the implantation period. These results indicated that hm‐ApGltn adhesives have potential applications in type‐A aortic dissection. |
author2 |
Uehara Memorial Foundation Japan Society for the Promotion of Science |
format |
Article in Journal/Newspaper |
author |
Ito, Temmei Mizuta, Ryo Ito, Shima Taguchi, Tetsushi |
spellingShingle |
Ito, Temmei Mizuta, Ryo Ito, Shima Taguchi, Tetsushi Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
author_facet |
Ito, Temmei Mizuta, Ryo Ito, Shima Taguchi, Tetsushi |
author_sort |
Ito, Temmei |
title |
Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
title_short |
Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
title_full |
Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
title_fullStr |
Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
title_full_unstemmed |
Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin‐based adhesive for aortic dissections |
title_sort |
robust aortic media adhesion using hydrophobically modified alaska pollock gelatin‐based adhesive for aortic dissections |
publisher |
Wiley |
publishDate |
2024 |
url |
http://dx.doi.org/10.1002/jbm.b.35361 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.35361 |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Journal of Biomedical Materials Research Part B: Applied Biomaterials volume 112, issue 1 ISSN 1552-4973 1552-4981 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jbm.b.35361 |
container_title |
Journal of Biomedical Materials Research Part B: Applied Biomaterials |
container_volume |
112 |
container_issue |
1 |
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1800736958267260928 |