Chitosan coatings with enhanced biostability in vivo
Abstract In this article, we study the stability of chitosan coatings applied on glutaraldehyde‐stabilized bovine pericardium when exposed to biodegradation in vivo in the course of model subcutaneous tests on rats. The coatings were deposited from carbonic acid solutions, that is, H 2 O saturated w...
Published in: | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
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crwiley:10.1002/jbm.b.33852 2024-09-15T18:01:38+00:00 Chitosan coatings with enhanced biostability in vivo Gallyamov, Marat O. Chaschin, Ivan S. Bulat, Matvey V. Bakuleva, Natalia P. Badun, Gennadii A. Chernysheva, Maria G. Kiselyova, Olga I. Khokhlov, Alexei R. Russian Foundation for Basic Research 2017 http://dx.doi.org/10.1002/jbm.b.33852 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbm.b.33852 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.33852 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Biomedical Materials Research Part B: Applied Biomaterials volume 106, issue 1, page 270-277 ISSN 1552-4973 1552-4981 journal-article 2017 crwiley https://doi.org/10.1002/jbm.b.33852 2024-09-05T05:03:23Z Abstract In this article, we study the stability of chitosan coatings applied on glutaraldehyde‐stabilized bovine pericardium when exposed to biodegradation in vivo in the course of model subcutaneous tests on rats. The coatings were deposited from carbonic acid solutions, that is, H 2 O saturated with CO 2 at high pressure. Histological sections of treated pericardium samples demonstrated that the structure of pericardial connective tissues was not significantly altered by the coating application method. It was revealed that the dynamics of biodegradation depended on the total mass of chitosan applied as well as on the DDA of chitosan used. As long as the amount of chitosan did not exceed a certain threshold limit, no detectable degradation occurred within the time of the tests (12 weeks for the rat model). For higher chitosan amounts, we detected a ∼20% reduction of the mass after the in vivo exposition. The presumed mechanism of such behavior is discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 270–277, 2018. Article in Journal/Newspaper Carbonic acid Wiley Online Library Journal of Biomedical Materials Research Part B: Applied Biomaterials 106 1 270 277 |
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English |
description |
Abstract In this article, we study the stability of chitosan coatings applied on glutaraldehyde‐stabilized bovine pericardium when exposed to biodegradation in vivo in the course of model subcutaneous tests on rats. The coatings were deposited from carbonic acid solutions, that is, H 2 O saturated with CO 2 at high pressure. Histological sections of treated pericardium samples demonstrated that the structure of pericardial connective tissues was not significantly altered by the coating application method. It was revealed that the dynamics of biodegradation depended on the total mass of chitosan applied as well as on the DDA of chitosan used. As long as the amount of chitosan did not exceed a certain threshold limit, no detectable degradation occurred within the time of the tests (12 weeks for the rat model). For higher chitosan amounts, we detected a ∼20% reduction of the mass after the in vivo exposition. The presumed mechanism of such behavior is discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 270–277, 2018. |
author2 |
Russian Foundation for Basic Research |
format |
Article in Journal/Newspaper |
author |
Gallyamov, Marat O. Chaschin, Ivan S. Bulat, Matvey V. Bakuleva, Natalia P. Badun, Gennadii A. Chernysheva, Maria G. Kiselyova, Olga I. Khokhlov, Alexei R. |
spellingShingle |
Gallyamov, Marat O. Chaschin, Ivan S. Bulat, Matvey V. Bakuleva, Natalia P. Badun, Gennadii A. Chernysheva, Maria G. Kiselyova, Olga I. Khokhlov, Alexei R. Chitosan coatings with enhanced biostability in vivo |
author_facet |
Gallyamov, Marat O. Chaschin, Ivan S. Bulat, Matvey V. Bakuleva, Natalia P. Badun, Gennadii A. Chernysheva, Maria G. Kiselyova, Olga I. Khokhlov, Alexei R. |
author_sort |
Gallyamov, Marat O. |
title |
Chitosan coatings with enhanced biostability in vivo |
title_short |
Chitosan coatings with enhanced biostability in vivo |
title_full |
Chitosan coatings with enhanced biostability in vivo |
title_fullStr |
Chitosan coatings with enhanced biostability in vivo |
title_full_unstemmed |
Chitosan coatings with enhanced biostability in vivo |
title_sort |
chitosan coatings with enhanced biostability in vivo |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1002/jbm.b.33852 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbm.b.33852 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.33852 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Journal of Biomedical Materials Research Part B: Applied Biomaterials volume 106, issue 1, page 270-277 ISSN 1552-4973 1552-4981 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/jbm.b.33852 |
container_title |
Journal of Biomedical Materials Research Part B: Applied Biomaterials |
container_volume |
106 |
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1 |
container_start_page |
270 |
op_container_end_page |
277 |
_version_ |
1810438744245796864 |