Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study
Abstract The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population‐based cohort of childhood cancer survivors. A cohort of 26 334 1‐yea...
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Online Access: | http://dx.doi.org/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.33741 |
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crwiley:10.1002/ijc.33741 2024-05-19T07:42:54+00:00 Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study Oskarsson, Trausti Duun‐Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila‐Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat‐Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck Barncancerfonden 2021 http://dx.doi.org/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.33741 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ International Journal of Cancer volume 149, issue 11, page 1863-1876 ISSN 0020-7136 1097-0215 journal-article 2021 crwiley https://doi.org/10.1002/ijc.33741 2024-04-25T08:29:26Z Abstract The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population‐based cohort of childhood cancer survivors. A cohort of 26 334 1‐year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age‐ and sex‐matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first‐time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29‐1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0‐44.5), osteoporosis, RR 4.53 (3.28‐6.27), fractures, RR 1.27 (1.20‐1.34), osteochondropathies, RR 1.57 (1.28‐1.92) and osteoarthrosis, RR 1.48 (1.28‐1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high‐risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. Article in Journal/Newspaper Iceland Wiley Online Library International Journal of Cancer 149 11 1863 1876 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population‐based cohort of childhood cancer survivors. A cohort of 26 334 1‐year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age‐ and sex‐matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first‐time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29‐1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0‐44.5), osteoporosis, RR 4.53 (3.28‐6.27), fractures, RR 1.27 (1.20‐1.34), osteochondropathies, RR 1.57 (1.28‐1.92) and osteoarthrosis, RR 1.48 (1.28‐1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high‐risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. |
author2 |
Barncancerfonden |
format |
Article in Journal/Newspaper |
author |
Oskarsson, Trausti Duun‐Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila‐Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat‐Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
spellingShingle |
Oskarsson, Trausti Duun‐Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila‐Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat‐Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
author_facet |
Oskarsson, Trausti Duun‐Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila‐Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat‐Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
author_sort |
Oskarsson, Trausti |
title |
Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_short |
Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full |
Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_fullStr |
Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full_unstemmed |
Skeletal adverse events in childhood cancer survivors: An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_sort |
skeletal adverse events in childhood cancer survivors: an adult life after childhood cancer in scandinavia cohort study |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.33741 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.33741 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer volume 149, issue 11, page 1863-1876 ISSN 0020-7136 1097-0215 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1002/ijc.33741 |
container_title |
International Journal of Cancer |
container_volume |
149 |
container_issue |
11 |
container_start_page |
1863 |
op_container_end_page |
1876 |
_version_ |
1799482602551246848 |