Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study
Free thiol groups of intra and extracellular molecules are considered to be antioxidative and to protect cells from damage caused by free radicals. However, the associations of serum total thiol levels (TTL) with the incidences of the four most frequent cancer sites have not yet been investigated in...
Published in: | International Journal of Cancer |
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crwiley:10.1002/ijc.32428 2024-09-15T18:39:24+00:00 Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study Gào, Xīn Wilsgaard, Tom Jansen, Eugène H. J. M. Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben China Scholarship Council Deutsche Forschungsgemeinschaft Universitetet i Tromsø EkstraStiftelsen Helse og Rehabilitering Northern Norway Regional Health Authority Norges Forskningsråd 2019 http://dx.doi.org/10.1002/ijc.32428 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.32428 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32428 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.32428 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 146, issue 5, page 1261-1267 ISSN 0020-7136 1097-0215 journal-article 2019 crwiley https://doi.org/10.1002/ijc.32428 2024-08-09T04:31:03Z Free thiol groups of intra and extracellular molecules are considered to be antioxidative and to protect cells from damage caused by free radicals. However, the associations of serum total thiol levels (TTL) with the incidences of the four most frequent cancer sites have not yet been investigated in a large population‐based, prospective study. TTL was measured in case–cohort design in a sample from the population‐based, Norwegian Tromsø 3 study (cancer cases: n = 941; random subcohort: n = 1,000) and was repeatedly measured at Tromsø 5. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated by weighted multivariable‐adjusted Cox regression with time‐dependent modeling of TTL for incident lung, colorectal, breast and prostate cancer. High serum TTL were associated with a reduced risk of all four major cancers. The associations with lung (top vs . bottom tertile: HR, 0.64; 95% CI, 0.41, 0.99) and breast cancer (top vs . bottom tertile: HR, 0.64; 95% CI, 0.42, 0.96) were statistically significant, whereas associations with colorectal (top vs . bottom tertile: HR, 0.79; 95% CI, 0.54, 1.16) and prostate cancer (top vs . bottom tertile: HR, 0.79; 95% CI, 0.53, 1.17) were not statistically significant but pointed in the same protective direction. These findings from a large, prospective Norwegian cohort study suggest a preventive role of thiols against the development of the four most frequent cancers. Whereas associations with breast and lung cancer could be shown with statistical significance, larger studies are needed to corroborate potential associations of TTL with colorectal and prostate cancer. Article in Journal/Newspaper Tromsø Wiley Online Library International Journal of Cancer 146 5 1261 1267 |
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Wiley Online Library |
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crwiley |
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English |
description |
Free thiol groups of intra and extracellular molecules are considered to be antioxidative and to protect cells from damage caused by free radicals. However, the associations of serum total thiol levels (TTL) with the incidences of the four most frequent cancer sites have not yet been investigated in a large population‐based, prospective study. TTL was measured in case–cohort design in a sample from the population‐based, Norwegian Tromsø 3 study (cancer cases: n = 941; random subcohort: n = 1,000) and was repeatedly measured at Tromsø 5. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated by weighted multivariable‐adjusted Cox regression with time‐dependent modeling of TTL for incident lung, colorectal, breast and prostate cancer. High serum TTL were associated with a reduced risk of all four major cancers. The associations with lung (top vs . bottom tertile: HR, 0.64; 95% CI, 0.41, 0.99) and breast cancer (top vs . bottom tertile: HR, 0.64; 95% CI, 0.42, 0.96) were statistically significant, whereas associations with colorectal (top vs . bottom tertile: HR, 0.79; 95% CI, 0.54, 1.16) and prostate cancer (top vs . bottom tertile: HR, 0.79; 95% CI, 0.53, 1.17) were not statistically significant but pointed in the same protective direction. These findings from a large, prospective Norwegian cohort study suggest a preventive role of thiols against the development of the four most frequent cancers. Whereas associations with breast and lung cancer could be shown with statistical significance, larger studies are needed to corroborate potential associations of TTL with colorectal and prostate cancer. |
author2 |
China Scholarship Council Deutsche Forschungsgemeinschaft Universitetet i Tromsø EkstraStiftelsen Helse og Rehabilitering Northern Norway Regional Health Authority Norges Forskningsråd |
format |
Article in Journal/Newspaper |
author |
Gào, Xīn Wilsgaard, Tom Jansen, Eugène H. J. M. Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben |
spellingShingle |
Gào, Xīn Wilsgaard, Tom Jansen, Eugène H. J. M. Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
author_facet |
Gào, Xīn Wilsgaard, Tom Jansen, Eugène H. J. M. Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben |
author_sort |
Gào, Xīn |
title |
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
title_short |
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
title_full |
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
title_fullStr |
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
title_full_unstemmed |
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case–cohort study |
title_sort |
serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: a prospective case–cohort study |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1002/ijc.32428 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.32428 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32428 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.32428 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
International Journal of Cancer volume 146, issue 5, page 1261-1267 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.32428 |
container_title |
International Journal of Cancer |
container_volume |
146 |
container_issue |
5 |
container_start_page |
1261 |
op_container_end_page |
1267 |
_version_ |
1810483773247062016 |