Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study
Large, comprehensive studies of the risk for neurologic disorders among long‐term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non‐CNS childhood cancer survivors for neurologic disorders. We identifie...
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Online Access: | http://dx.doi.org/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.32341 |
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crwiley:10.1002/ijc.32341 2024-06-02T08:09:24+00:00 Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study Kenborg, Line Linnet, Karen M. de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S. Tryggvadottir, Laufey Madanat‐Harjuoja, Laura M. Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F. Børnecancerfonden Dansk Kræftforsknings Fond 2019 http://dx.doi.org/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.32341 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 146, issue 3, page 819-828 ISSN 0020-7136 1097-0215 journal-article 2019 crwiley https://doi.org/10.1002/ijc.32341 2024-05-03T11:49:10Z Large, comprehensive studies of the risk for neurologic disorders among long‐term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non‐CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5‐year survivors of non‐CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943–2008, and 151,118 matched population comparison subjects. In‐patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9–2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2–5.3) and leukemia (2.8; 95% CI 2.4–3.2). The AER decreased from 331 (278–383) excess neurologic disorders per 100,000 person‐years 5–9 years after diagnosis to 82 (46–118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis ( n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non‐CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow‐up to identify those who require close management is needed. Article in Journal/Newspaper Iceland Wiley Online Library International Journal of Cancer 146 3 819 828 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Large, comprehensive studies of the risk for neurologic disorders among long‐term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non‐CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5‐year survivors of non‐CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943–2008, and 151,118 matched population comparison subjects. In‐patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9–2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2–5.3) and leukemia (2.8; 95% CI 2.4–3.2). The AER decreased from 331 (278–383) excess neurologic disorders per 100,000 person‐years 5–9 years after diagnosis to 82 (46–118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis ( n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non‐CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow‐up to identify those who require close management is needed. |
author2 |
Børnecancerfonden Dansk Kræftforsknings Fond |
format |
Article in Journal/Newspaper |
author |
Kenborg, Line Linnet, Karen M. de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S. Tryggvadottir, Laufey Madanat‐Harjuoja, Laura M. Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F. |
spellingShingle |
Kenborg, Line Linnet, Karen M. de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S. Tryggvadottir, Laufey Madanat‐Harjuoja, Laura M. Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F. Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
author_facet |
Kenborg, Line Linnet, Karen M. de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S. Tryggvadottir, Laufey Madanat‐Harjuoja, Laura M. Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F. |
author_sort |
Kenborg, Line |
title |
Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_short |
Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_full |
Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_fullStr |
Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_full_unstemmed |
Hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_sort |
hospital admission for neurologic disorders among 5‐year survivors of noncentral nervous system tumors in childhood: a cohort study within the adult life after childhood cancer in scandinavia study |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32341 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.32341 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer volume 146, issue 3, page 819-828 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.32341 |
container_title |
International Journal of Cancer |
container_volume |
146 |
container_issue |
3 |
container_start_page |
819 |
op_container_end_page |
828 |
_version_ |
1800755122979995648 |