Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study
Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer‐directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors...
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Online Access: | http://dx.doi.org/10.1002/ijc.30198 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.30198 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.30198 |
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crwiley:10.1002/ijc.30198 2024-06-02T08:09:25+00:00 Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study Asdahl, Peter Haubjerg Winther, Jeanette Falck Bonnesen, Trine Gade De Fine Licht, Sofie Gudmundsdottir, Thorgerdur Holmqvist, Anna Sällfors Malila, Nea Tryggvadottir, Laufey Wesenberg, Finn Dahlerup, Jens Frederik Olsen, Jørgen Helge Hasle, Henrik Danish Council for Strategic Research Danish Child Cancer Foundation 2016 http://dx.doi.org/10.1002/ijc.30198 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.30198 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.30198 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 139, issue 7, page 1501-1511 ISSN 0020-7136 1097-0215 journal-article 2016 crwiley https://doi.org/10.1002/ijc.30198 2024-05-03T11:10:50Z Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer‐directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population‐based cohort study included all 1‐year survivors of childhood and adolescent cancer in Denmark, Finland, Iceland, Norway and Sweden diagnosed from the 1940s and 1950s. Our outcomes of interest were hospitalization rates for gastrointestinal and liver diseases, which were ascertained from national patient registries. We calculated standardized hospitalization rate ratios (RRs) and absolute excess rates comparing hospitalizations of any gastrointestinal or liver disease and for specific disease entities between survivors and the general population. The study included 31,132 survivors and 207,041 comparison subjects. The median follow‐up in the hospital registries were 10 years (range: 0–42) with 23% of the survivors being followed at least to the age of 40 years. Overall, survivors had a 60% relative excess of gastrointestinal or liver diseases [RR: 1.6, 95% confidence interval (CI): 1.6–1.7], which corresponds to an absolute excess of 360 (95% CI: 330–390) hospitalizations per 100,000 person‐years. Survivors of hepatic tumors, neuroblastoma and leukemia had the highest excess of gastrointestinal and liver diseases. In addition, we observed a relative excess of several specific diseases such as esophageal stricture (RR: 13; 95% CI: 9.2–20) and liver cirrhosis (RR: 2.9; 95% CI: 2.0–4.1). Our findings provide useful information about the breadth and magnitude of late complications among childhood cancer survivors and can be used for generating hypotheses about potential exposures related to these gastrointestinal and liver late effects. Article in Journal/Newspaper Iceland Wiley Online Library Norway International Journal of Cancer 139 7 1501 1511 |
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Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer‐directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population‐based cohort study included all 1‐year survivors of childhood and adolescent cancer in Denmark, Finland, Iceland, Norway and Sweden diagnosed from the 1940s and 1950s. Our outcomes of interest were hospitalization rates for gastrointestinal and liver diseases, which were ascertained from national patient registries. We calculated standardized hospitalization rate ratios (RRs) and absolute excess rates comparing hospitalizations of any gastrointestinal or liver disease and for specific disease entities between survivors and the general population. The study included 31,132 survivors and 207,041 comparison subjects. The median follow‐up in the hospital registries were 10 years (range: 0–42) with 23% of the survivors being followed at least to the age of 40 years. Overall, survivors had a 60% relative excess of gastrointestinal or liver diseases [RR: 1.6, 95% confidence interval (CI): 1.6–1.7], which corresponds to an absolute excess of 360 (95% CI: 330–390) hospitalizations per 100,000 person‐years. Survivors of hepatic tumors, neuroblastoma and leukemia had the highest excess of gastrointestinal and liver diseases. In addition, we observed a relative excess of several specific diseases such as esophageal stricture (RR: 13; 95% CI: 9.2–20) and liver cirrhosis (RR: 2.9; 95% CI: 2.0–4.1). Our findings provide useful information about the breadth and magnitude of late complications among childhood cancer survivors and can be used for generating hypotheses about potential exposures related to these gastrointestinal and liver late effects. |
author2 |
Danish Council for Strategic Research Danish Child Cancer Foundation |
format |
Article in Journal/Newspaper |
author |
Asdahl, Peter Haubjerg Winther, Jeanette Falck Bonnesen, Trine Gade De Fine Licht, Sofie Gudmundsdottir, Thorgerdur Holmqvist, Anna Sällfors Malila, Nea Tryggvadottir, Laufey Wesenberg, Finn Dahlerup, Jens Frederik Olsen, Jørgen Helge Hasle, Henrik |
spellingShingle |
Asdahl, Peter Haubjerg Winther, Jeanette Falck Bonnesen, Trine Gade De Fine Licht, Sofie Gudmundsdottir, Thorgerdur Holmqvist, Anna Sällfors Malila, Nea Tryggvadottir, Laufey Wesenberg, Finn Dahlerup, Jens Frederik Olsen, Jørgen Helge Hasle, Henrik Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
author_facet |
Asdahl, Peter Haubjerg Winther, Jeanette Falck Bonnesen, Trine Gade De Fine Licht, Sofie Gudmundsdottir, Thorgerdur Holmqvist, Anna Sällfors Malila, Nea Tryggvadottir, Laufey Wesenberg, Finn Dahlerup, Jens Frederik Olsen, Jørgen Helge Hasle, Henrik |
author_sort |
Asdahl, Peter Haubjerg |
title |
Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
title_short |
Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
title_full |
Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
title_fullStr |
Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
title_full_unstemmed |
Gastrointestinal and liver disease in Adult Life After Childhood Cancer in Scandinavia: A population‐based cohort study |
title_sort |
gastrointestinal and liver disease in adult life after childhood cancer in scandinavia: a population‐based cohort study |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1002/ijc.30198 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.30198 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.30198 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer volume 139, issue 7, page 1501-1511 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.30198 |
container_title |
International Journal of Cancer |
container_volume |
139 |
container_issue |
7 |
container_start_page |
1501 |
op_container_end_page |
1511 |
_version_ |
1800755136545423360 |