Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study
Insulin‐like growth factor‐I (IGF‐I) signaling may promote ovarian tumor development by exerting mitotic, antiapoptotic and proangiogenic effects. During pregnancy, maternal production of IGF‐I is regulated by placental growth hormone (GH). Parity is an established protective factor for ovarian canc...
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crwiley:10.1002/ijc.29387 2024-06-02T08:12:13+00:00 Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study Schock, Helena Fortner, Renée T. Surcel, Heljä‐Marja Grankvist, Kjell Pukkala, Eero Lehtinen, Matti Lundin, Eva National Cancer Institute Lion's Cancer Foundation at Umea University Sweden 2014 http://dx.doi.org/10.1002/ijc.29387 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.29387 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.29387 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 137, issue 2, page 439-447 ISSN 0020-7136 1097-0215 journal-article 2014 crwiley https://doi.org/10.1002/ijc.29387 2024-05-03T10:45:21Z Insulin‐like growth factor‐I (IGF‐I) signaling may promote ovarian tumor development by exerting mitotic, antiapoptotic and proangiogenic effects. During pregnancy, maternal production of IGF‐I is regulated by placental growth hormone (GH). Parity is an established protective factor for ovarian cancer, however, no prior study has evaluated placental GH and IGF‐I in pregnancy and epithelial ovarian cancer (EOC). Prior prospective studies on the association between IGF‐I and EOC in nonpregnant populations were inconclusive and did not address associations in subtypes of EOC. Among members of the Finnish Maternity Cohort and the Northern Sweden Maternity Cohort, we identified 1,045 EOC cases, diagnosed after recruitment (1975–2008) and before March 2011 and 2,658 individually matched controls. Placental GH and IGF‐I were measured in serum from the last pregnancy before EOC diagnosis or selection as control. We used conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for tertiles and a doubling of hormone concentrations. Higher IGF‐I was associated with a nonsignificant decrease in risk for invasive [OR T3 vs. T1 : 0.79 (0.62–1.02); p trend = 0.07] and endometrioid tumors [OR T3 vs. T1 : 0.55 (0.28–1.07); p trend = 0.07]. The protective association between higher IGF‐I levels and risk of invasive EOC was stronger in analyses limited to women aged <55 years at diagnosis [OR T3 vs. T1 : 0.74 (0.57–0.96); p trend = 0.03]. Our study provides the first data on placental GH and IGF‐I in pregnancy and EOC risk overall and by subtype. Our data suggest higher IGF‐I levels in pregnancy may be associated with lower risk of invasive and endometrioid EOC. Article in Journal/Newspaper Northern Sweden Wiley Online Library International Journal of Cancer 137 2 439 447 |
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Wiley Online Library |
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English |
description |
Insulin‐like growth factor‐I (IGF‐I) signaling may promote ovarian tumor development by exerting mitotic, antiapoptotic and proangiogenic effects. During pregnancy, maternal production of IGF‐I is regulated by placental growth hormone (GH). Parity is an established protective factor for ovarian cancer, however, no prior study has evaluated placental GH and IGF‐I in pregnancy and epithelial ovarian cancer (EOC). Prior prospective studies on the association between IGF‐I and EOC in nonpregnant populations were inconclusive and did not address associations in subtypes of EOC. Among members of the Finnish Maternity Cohort and the Northern Sweden Maternity Cohort, we identified 1,045 EOC cases, diagnosed after recruitment (1975–2008) and before March 2011 and 2,658 individually matched controls. Placental GH and IGF‐I were measured in serum from the last pregnancy before EOC diagnosis or selection as control. We used conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for tertiles and a doubling of hormone concentrations. Higher IGF‐I was associated with a nonsignificant decrease in risk for invasive [OR T3 vs. T1 : 0.79 (0.62–1.02); p trend = 0.07] and endometrioid tumors [OR T3 vs. T1 : 0.55 (0.28–1.07); p trend = 0.07]. The protective association between higher IGF‐I levels and risk of invasive EOC was stronger in analyses limited to women aged <55 years at diagnosis [OR T3 vs. T1 : 0.74 (0.57–0.96); p trend = 0.03]. Our study provides the first data on placental GH and IGF‐I in pregnancy and EOC risk overall and by subtype. Our data suggest higher IGF‐I levels in pregnancy may be associated with lower risk of invasive and endometrioid EOC. |
author2 |
National Cancer Institute Lion's Cancer Foundation at Umea University Sweden |
format |
Article in Journal/Newspaper |
author |
Schock, Helena Fortner, Renée T. Surcel, Heljä‐Marja Grankvist, Kjell Pukkala, Eero Lehtinen, Matti Lundin, Eva |
spellingShingle |
Schock, Helena Fortner, Renée T. Surcel, Heljä‐Marja Grankvist, Kjell Pukkala, Eero Lehtinen, Matti Lundin, Eva Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
author_facet |
Schock, Helena Fortner, Renée T. Surcel, Heljä‐Marja Grankvist, Kjell Pukkala, Eero Lehtinen, Matti Lundin, Eva |
author_sort |
Schock, Helena |
title |
Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
title_short |
Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
title_full |
Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
title_fullStr |
Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
title_full_unstemmed |
Early pregnancy IGF‐I and placental GH and risk of epithelial ovarian cancer: A nested case‐control study |
title_sort |
early pregnancy igf‐i and placental gh and risk of epithelial ovarian cancer: a nested case‐control study |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/ijc.29387 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.29387 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.29387 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
International Journal of Cancer volume 137, issue 2, page 439-447 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.29387 |
container_title |
International Journal of Cancer |
container_volume |
137 |
container_issue |
2 |
container_start_page |
439 |
op_container_end_page |
447 |
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1800758594731245568 |