Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma
Abstract In a comparative study of populations at high and low risk of nasopharyngeal carcinoma (NPC), sera from 442 Eskimo and 770 Danish children and adolescents were tested for the presence of antibodies against Epstein‐Barr virus (EBV). Eskimo children in Greenland were seropositive at an early...
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crwiley:10.1002/ijc.2910340506 2024-06-02T08:06:10+00:00 Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma Melbye, Mads Ebbesen, Peter Levine, Paul H. Bennike, Torbjørn 1984 http://dx.doi.org/10.1002/ijc.2910340506 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.2910340506 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.2910340506 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 34, issue 5, page 619-623 ISSN 0020-7136 1097-0215 journal-article 1984 crwiley https://doi.org/10.1002/ijc.2910340506 2024-05-03T11:38:26Z Abstract In a comparative study of populations at high and low risk of nasopharyngeal carcinoma (NPC), sera from 442 Eskimo and 770 Danish children and adolescents were tested for the presence of antibodies against Epstein‐Barr virus (EBV). Eskimo children in Greenland were seropositive at an early age and showed significantly higher titers of IgG antibody to the viral capsid antigen (VCA) ( p <0.0001) and soluble (S) antigen ( p <.005) than Danes matched for age and sex, but had similar levels of IgA antibody to VCA and IgG antibody to the early antigen (EA). The high geometric mean VCA (IgG) titers found in certain age groups of Eskimo children were as high as those previously reported from areas in Africa highly endemic for Burkitt's lymphoma. In Greenland, neither location nor household size was a determining factor for prevalence or titer of VCA (IgG). The high antibody titers among Eskimo children probably reflect exposure to a large inoculum of EBV at the time of primary infection, infection early in life and/or re‐exposure due to the higher incidence of EBV infection in Greenland. In view of the high incidence of NPC in Greenland and the known association of this tumor with EBV, we speculate that the time and quantitative aspects of the primary infection are also factors of relevance in the etiology of NPC. Article in Journal/Newspaper eskimo* Greenland Wiley Online Library Greenland International Journal of Cancer 34 5 619 623 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract In a comparative study of populations at high and low risk of nasopharyngeal carcinoma (NPC), sera from 442 Eskimo and 770 Danish children and adolescents were tested for the presence of antibodies against Epstein‐Barr virus (EBV). Eskimo children in Greenland were seropositive at an early age and showed significantly higher titers of IgG antibody to the viral capsid antigen (VCA) ( p <0.0001) and soluble (S) antigen ( p <.005) than Danes matched for age and sex, but had similar levels of IgA antibody to VCA and IgG antibody to the early antigen (EA). The high geometric mean VCA (IgG) titers found in certain age groups of Eskimo children were as high as those previously reported from areas in Africa highly endemic for Burkitt's lymphoma. In Greenland, neither location nor household size was a determining factor for prevalence or titer of VCA (IgG). The high antibody titers among Eskimo children probably reflect exposure to a large inoculum of EBV at the time of primary infection, infection early in life and/or re‐exposure due to the higher incidence of EBV infection in Greenland. In view of the high incidence of NPC in Greenland and the known association of this tumor with EBV, we speculate that the time and quantitative aspects of the primary infection are also factors of relevance in the etiology of NPC. |
format |
Article in Journal/Newspaper |
author |
Melbye, Mads Ebbesen, Peter Levine, Paul H. Bennike, Torbjørn |
spellingShingle |
Melbye, Mads Ebbesen, Peter Levine, Paul H. Bennike, Torbjørn Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
author_facet |
Melbye, Mads Ebbesen, Peter Levine, Paul H. Bennike, Torbjørn |
author_sort |
Melbye, Mads |
title |
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
title_short |
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
title_full |
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
title_fullStr |
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
title_full_unstemmed |
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
title_sort |
early primary infection and high epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma |
publisher |
Wiley |
publishDate |
1984 |
url |
http://dx.doi.org/10.1002/ijc.2910340506 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.2910340506 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.2910340506 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland |
genre_facet |
eskimo* Greenland |
op_source |
International Journal of Cancer volume 34, issue 5, page 619-623 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.2910340506 |
container_title |
International Journal of Cancer |
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34 |
container_issue |
5 |
container_start_page |
619 |
op_container_end_page |
623 |
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1800751076809375744 |