Cancer incidence among Nordic airline cabin crew
Abstract Airline cabin crew are occupationally exposed to cosmic radiation and jet lag with potential disruption of circadian rhythms. This study assesses the influence of work‐related factors in cancer incidence of cabin crew members. A cohort of 8,507 female and 1,559 male airline cabin attendants...
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crwiley:10.1002/ijc.27551 2024-09-15T18:14:19+00:00 Cancer incidence among Nordic airline cabin crew Pukkala, Eero Helminen, Mika Haldorsen, Tor Hammar, Niklas Kojo, Katja Linnersjö, Anette Rafnsson, Vilhjálmur Tulinius, Hrafn Tveten, Ulf Auvinen, Anssi 2012 http://dx.doi.org/10.1002/ijc.27551 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.27551 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.27551 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 131, issue 12, page 2886-2897 ISSN 0020-7136 1097-0215 journal-article 2012 crwiley https://doi.org/10.1002/ijc.27551 2024-08-27T04:27:31Z Abstract Airline cabin crew are occupationally exposed to cosmic radiation and jet lag with potential disruption of circadian rhythms. This study assesses the influence of work‐related factors in cancer incidence of cabin crew members. A cohort of 8,507 female and 1,559 male airline cabin attendants from Finland, Iceland, Norway and Sweden was followed for cancer incidence for a mean follow‐up time of 23.6 years through the national cancer registries. Standardized incidence ratios (SIRs) were defined as ratios of observed and expected numbers of cases. A case‐control study nested in the cohort (excluding Norway) was conducted to assess the relation between the estimated cumulative cosmic radiation dose and cumulative number of flights crossing six time zones (indicator of circadian disruption) and cancer risk. Analysis of breast cancer was adjusted for parity and age at first live birth. Among female cabin crew, a significantly increased incidence was observed for breast cancer [SIR 1.50, 95% confidence interval (95% CI) 1.32–1.69], leukemia (1.89, 95% CI 1.03–3.17) and skin melanoma (1.85, 95% CI 1.41–2.38). Among men, significant excesses in skin melanoma (3.00, 95% CI 1.78–4.74), nonmelanoma skin cancer (2.47, 95% CI 1.18–4.53), Kaposi sarcoma (86.0, 95% CI 41.2–158) and alcohol‐related cancers (combined SIR 3.12, 95% CI 1.95–4.72) were found. This large study with complete follow‐up and comprehensive cancer incidence data shows an increased incidence of several cancers, but according to the case‐control analysis, excesses appear not to be related to the cosmic radiation or circadian disruptions from crossing multiple time zones. Article in Journal/Newspaper Iceland Wiley Online Library International Journal of Cancer 131 12 2886 2897 |
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Wiley Online Library |
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English |
description |
Abstract Airline cabin crew are occupationally exposed to cosmic radiation and jet lag with potential disruption of circadian rhythms. This study assesses the influence of work‐related factors in cancer incidence of cabin crew members. A cohort of 8,507 female and 1,559 male airline cabin attendants from Finland, Iceland, Norway and Sweden was followed for cancer incidence for a mean follow‐up time of 23.6 years through the national cancer registries. Standardized incidence ratios (SIRs) were defined as ratios of observed and expected numbers of cases. A case‐control study nested in the cohort (excluding Norway) was conducted to assess the relation between the estimated cumulative cosmic radiation dose and cumulative number of flights crossing six time zones (indicator of circadian disruption) and cancer risk. Analysis of breast cancer was adjusted for parity and age at first live birth. Among female cabin crew, a significantly increased incidence was observed for breast cancer [SIR 1.50, 95% confidence interval (95% CI) 1.32–1.69], leukemia (1.89, 95% CI 1.03–3.17) and skin melanoma (1.85, 95% CI 1.41–2.38). Among men, significant excesses in skin melanoma (3.00, 95% CI 1.78–4.74), nonmelanoma skin cancer (2.47, 95% CI 1.18–4.53), Kaposi sarcoma (86.0, 95% CI 41.2–158) and alcohol‐related cancers (combined SIR 3.12, 95% CI 1.95–4.72) were found. This large study with complete follow‐up and comprehensive cancer incidence data shows an increased incidence of several cancers, but according to the case‐control analysis, excesses appear not to be related to the cosmic radiation or circadian disruptions from crossing multiple time zones. |
format |
Article in Journal/Newspaper |
author |
Pukkala, Eero Helminen, Mika Haldorsen, Tor Hammar, Niklas Kojo, Katja Linnersjö, Anette Rafnsson, Vilhjálmur Tulinius, Hrafn Tveten, Ulf Auvinen, Anssi |
spellingShingle |
Pukkala, Eero Helminen, Mika Haldorsen, Tor Hammar, Niklas Kojo, Katja Linnersjö, Anette Rafnsson, Vilhjálmur Tulinius, Hrafn Tveten, Ulf Auvinen, Anssi Cancer incidence among Nordic airline cabin crew |
author_facet |
Pukkala, Eero Helminen, Mika Haldorsen, Tor Hammar, Niklas Kojo, Katja Linnersjö, Anette Rafnsson, Vilhjálmur Tulinius, Hrafn Tveten, Ulf Auvinen, Anssi |
author_sort |
Pukkala, Eero |
title |
Cancer incidence among Nordic airline cabin crew |
title_short |
Cancer incidence among Nordic airline cabin crew |
title_full |
Cancer incidence among Nordic airline cabin crew |
title_fullStr |
Cancer incidence among Nordic airline cabin crew |
title_full_unstemmed |
Cancer incidence among Nordic airline cabin crew |
title_sort |
cancer incidence among nordic airline cabin crew |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1002/ijc.27551 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.27551 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.27551 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer volume 131, issue 12, page 2886-2897 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.27551 |
container_title |
International Journal of Cancer |
container_volume |
131 |
container_issue |
12 |
container_start_page |
2886 |
op_container_end_page |
2897 |
_version_ |
1810452086907731968 |