Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study
Abstract The aim of this study was to investigate if a genetic risk score including 33 common genetic variants improves prediction of prostate cancer when added to measures of prostate‐specific antigen (PSA). We conducted a case–control study nested within the Northern Sweden Health and Disease Coho...
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crwiley:10.1002/ijc.25986 2024-06-02T08:12:09+00:00 Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study Johansson, Mattias Holmström, Benny Hinchliffe, Sally R. Bergh, Anders Stenman, Ulf‐Håkan Hallmans, Göran Wiklund, Fredrik Stattin, Pär 2011 http://dx.doi.org/10.1002/ijc.25986 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.25986 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.25986 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 130, issue 1, page 129-137 ISSN 0020-7136 1097-0215 journal-article 2011 crwiley https://doi.org/10.1002/ijc.25986 2024-05-03T11:37:41Z Abstract The aim of this study was to investigate if a genetic risk score including 33 common genetic variants improves prediction of prostate cancer when added to measures of prostate‐specific antigen (PSA). We conducted a case–control study nested within the Northern Sweden Health and Disease Cohort (NSHDC), a prospective cohort in northern Sweden. A total of 520 cases and 988 controls matched for age, and date of blood draw were identified by linkage between the regional cancer register and the NSHDC. Receiver operating characteristic curves with area under curve (AUC) estimates were used as measures of prostate cancer prediction. The AUC for the genetic risk score was 64.3% [95% confidence interval (CI) = 61.4–67.2], and the AUC for total PSA and the ratio of free to total PSA was 86.2% (95% CI = 84.4–88.1). A model including the genetic risk score, total PSA and the ratio of free to total PSA increased the AUC to 87.2% (95% CI = 85.4–89.0, p difference = 0.002). The addition of a genetic risk score to PSA resulted in a marginal improvement in prostate cancer prediction that would not seem useful for clinical risk assessment. Article in Journal/Newspaper Northern Sweden Wiley Online Library International Journal of Cancer 130 1 129 137 |
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Wiley Online Library |
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language |
English |
description |
Abstract The aim of this study was to investigate if a genetic risk score including 33 common genetic variants improves prediction of prostate cancer when added to measures of prostate‐specific antigen (PSA). We conducted a case–control study nested within the Northern Sweden Health and Disease Cohort (NSHDC), a prospective cohort in northern Sweden. A total of 520 cases and 988 controls matched for age, and date of blood draw were identified by linkage between the regional cancer register and the NSHDC. Receiver operating characteristic curves with area under curve (AUC) estimates were used as measures of prostate cancer prediction. The AUC for the genetic risk score was 64.3% [95% confidence interval (CI) = 61.4–67.2], and the AUC for total PSA and the ratio of free to total PSA was 86.2% (95% CI = 84.4–88.1). A model including the genetic risk score, total PSA and the ratio of free to total PSA increased the AUC to 87.2% (95% CI = 85.4–89.0, p difference = 0.002). The addition of a genetic risk score to PSA resulted in a marginal improvement in prostate cancer prediction that would not seem useful for clinical risk assessment. |
format |
Article in Journal/Newspaper |
author |
Johansson, Mattias Holmström, Benny Hinchliffe, Sally R. Bergh, Anders Stenman, Ulf‐Håkan Hallmans, Göran Wiklund, Fredrik Stattin, Pär |
spellingShingle |
Johansson, Mattias Holmström, Benny Hinchliffe, Sally R. Bergh, Anders Stenman, Ulf‐Håkan Hallmans, Göran Wiklund, Fredrik Stattin, Pär Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
author_facet |
Johansson, Mattias Holmström, Benny Hinchliffe, Sally R. Bergh, Anders Stenman, Ulf‐Håkan Hallmans, Göran Wiklund, Fredrik Stattin, Pär |
author_sort |
Johansson, Mattias |
title |
Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
title_short |
Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
title_full |
Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
title_fullStr |
Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
title_full_unstemmed |
Combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: Longitudinal study |
title_sort |
combining 33 genetic variants with prostate‐specific antigen for prediction of prostate cancer: longitudinal study |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1002/ijc.25986 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.25986 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.25986 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
International Journal of Cancer volume 130, issue 1, page 129-137 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.25986 |
container_title |
International Journal of Cancer |
container_volume |
130 |
container_issue |
1 |
container_start_page |
129 |
op_container_end_page |
137 |
_version_ |
1800758495639764992 |