Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer
Abstract Cancer risks for a person who has inherited a MUTYH mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first‐ and second‐degree relatives of 144 incident colo...
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crwiley:10.1002/ijc.25870 2024-09-15T18:20:15+00:00 Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer Win, Aung Ko Cleary, Sean P. Dowty, James G. Baron, John A. Young, Joanne P. Buchanan, Daniel D. Southey, Melissa C. Burnett, Terrilea Parfrey, Patrick S. Green, Roger C. Marchand, Loïc Le Newcomb, Polly A. Haile, Robert W. Lindor, Noralane M. Hopper, John L. Gallinger, Steven Jenkins, Mark A. 2011 http://dx.doi.org/10.1002/ijc.25870 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.25870 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.25870 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 129, issue 9, page 2256-2262 ISSN 0020-7136 1097-0215 journal-article 2011 crwiley https://doi.org/10.1002/ijc.25870 2024-08-06T04:21:20Z Abstract Cancer risks for a person who has inherited a MUTYH mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first‐ and second‐degree relatives of 144 incident colorectal cancer (CRC) cases who were monoallelic or biallelic mutation carriers ascertained by sampling population complete cancer registries in the United States, Canada and Australia. Using Cox regression weighted to adjust for sampling on family history, we estimated that the country‐, age‐ and sex‐specific standardized incidence ratios (SIRs) for monoallelic mutation carriers, compared to the general population, were: 2.04 (95% confidence interval, CI 1.56–2.70; p < 0.001) for CRC, 3.24 (95%CI 2.18–4.98; p < 0.001) for gastric cancer, 3.09 (95%CI 1.07–12.25; p = 0.07) for liver cancer and 2.33 (95%CI 1.18–5.08; p = 0.02) for endometrial cancer. Age‐specific cumulative risks to age 70 years, estimated using the SIRs and US population incidences, were: for CRC, 6% (95%CI 5–8%) for men and 4% (95%CI 3–6%) for women; for gastric cancer, 2% (95%CI 1–3%) for men and 0.7% (95%CI 0.5–1%) for women; for liver cancer, 1% (95%CI 0.3–3%) for men and 0.3% (95%CI 0.1–1%) for women and for endometrial cancer, 4% (95%CI 2–8%). There was no evidence of increased risks for cancers of the brain, pancreas, kidney, lung, breast or prostate. Monoallelic MUTYH mutation carriers with a family history of CRC, such as those identified from screening multiple‐case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers. Article in Journal/Newspaper Newfoundland Wiley Online Library International Journal of Cancer 129 9 2256 2262 |
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Abstract Cancer risks for a person who has inherited a MUTYH mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first‐ and second‐degree relatives of 144 incident colorectal cancer (CRC) cases who were monoallelic or biallelic mutation carriers ascertained by sampling population complete cancer registries in the United States, Canada and Australia. Using Cox regression weighted to adjust for sampling on family history, we estimated that the country‐, age‐ and sex‐specific standardized incidence ratios (SIRs) for monoallelic mutation carriers, compared to the general population, were: 2.04 (95% confidence interval, CI 1.56–2.70; p < 0.001) for CRC, 3.24 (95%CI 2.18–4.98; p < 0.001) for gastric cancer, 3.09 (95%CI 1.07–12.25; p = 0.07) for liver cancer and 2.33 (95%CI 1.18–5.08; p = 0.02) for endometrial cancer. Age‐specific cumulative risks to age 70 years, estimated using the SIRs and US population incidences, were: for CRC, 6% (95%CI 5–8%) for men and 4% (95%CI 3–6%) for women; for gastric cancer, 2% (95%CI 1–3%) for men and 0.7% (95%CI 0.5–1%) for women; for liver cancer, 1% (95%CI 0.3–3%) for men and 0.3% (95%CI 0.1–1%) for women and for endometrial cancer, 4% (95%CI 2–8%). There was no evidence of increased risks for cancers of the brain, pancreas, kidney, lung, breast or prostate. Monoallelic MUTYH mutation carriers with a family history of CRC, such as those identified from screening multiple‐case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers. |
format |
Article in Journal/Newspaper |
author |
Win, Aung Ko Cleary, Sean P. Dowty, James G. Baron, John A. Young, Joanne P. Buchanan, Daniel D. Southey, Melissa C. Burnett, Terrilea Parfrey, Patrick S. Green, Roger C. Marchand, Loïc Le Newcomb, Polly A. Haile, Robert W. Lindor, Noralane M. Hopper, John L. Gallinger, Steven Jenkins, Mark A. |
spellingShingle |
Win, Aung Ko Cleary, Sean P. Dowty, James G. Baron, John A. Young, Joanne P. Buchanan, Daniel D. Southey, Melissa C. Burnett, Terrilea Parfrey, Patrick S. Green, Roger C. Marchand, Loïc Le Newcomb, Polly A. Haile, Robert W. Lindor, Noralane M. Hopper, John L. Gallinger, Steven Jenkins, Mark A. Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
author_facet |
Win, Aung Ko Cleary, Sean P. Dowty, James G. Baron, John A. Young, Joanne P. Buchanan, Daniel D. Southey, Melissa C. Burnett, Terrilea Parfrey, Patrick S. Green, Roger C. Marchand, Loïc Le Newcomb, Polly A. Haile, Robert W. Lindor, Noralane M. Hopper, John L. Gallinger, Steven Jenkins, Mark A. |
author_sort |
Win, Aung Ko |
title |
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
title_short |
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
title_full |
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
title_fullStr |
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
title_full_unstemmed |
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer |
title_sort |
cancer risks for monoallelic mutyh mutation carriers with a family history of colorectal cancer |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1002/ijc.25870 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.25870 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.25870 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
International Journal of Cancer volume 129, issue 9, page 2256-2262 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.25870 |
container_title |
International Journal of Cancer |
container_volume |
129 |
container_issue |
9 |
container_start_page |
2256 |
op_container_end_page |
2262 |
_version_ |
1810458622410358784 |