Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer
Abstract Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel‐embedded magnetoliposomes (DMLs) and an applied alternat...
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crwiley:10.1002/ijc.24864 2024-06-23T07:52:22+00:00 Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer Yoshida, Motohira Watanabe, Yuji Sato, Mitsunori Maehara, Tsunehiro Aono, Hiromichi Naohara, Takashi Hirazawa, Hideyuki Horiuchi, Atsushi Yukumi, Shungo Sato, Koichi Nakagawa, Hiromichi Yamamoto, Yuji Sugishita, Hiroki Kawachi, Kanji 2009 http://dx.doi.org/10.1002/ijc.24864 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.24864 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.24864 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 126, issue 8, page 1955-1965 ISSN 0020-7136 1097-0215 journal-article 2009 crwiley https://doi.org/10.1002/ijc.24864 2024-06-13T04:23:52Z Abstract Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel‐embedded magnetoliposomes (DMLs) and an applied alternating current (AC) magnetic field. Human MKN45 gastric cancer cells were implanted in the hind limb of Balb‐c/nu/nu mice. Various concentrations of docetaxel‐embedded DMLs were injected into the tumors and exposed to an AC magnetic field ( n = 6, each). For comparison with hyperthermia alone, magnetite‐loaded liposome (ML)‐injected tumors were exposed to an AC magnetic field. Furthermore, the results of DML without AC treatment and docetaxel diluted into PBS with AC treatment were also compared ( n = 10, each). Tumor surface temperature was maintained between 42 and 43°C. Tumor volume was reduced in the DML group with a docetaxel concentration > 56.8 μg/ml, while a docetaxel concentration > 568.5 μg/ml was required for tumor reduction without hyperthermia. Statistically significant differences in tumor volume and survival rate were observed between the DML group exposed to the magnetic field and the other groups. The tumor disappeared in 3 mice in the DML group exposed to the magnetic field; 2 mice survived over 6 months after treatment, whereas all mice of the other groups died by 15 weeks. Histologically, hyperthermia with DML damaged tumor cells and DML diffused homogeneously. To the best of our knowledge, this is the first report to show that hyperthermia using chemotherapeutic agent‐embedded magnetoliposomes has an anticancer effect. Article in Journal/Newspaper DML Wiley Online Library International Journal of Cancer 126 8 1955 1965 |
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Wiley Online Library |
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English |
description |
Abstract Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel‐embedded magnetoliposomes (DMLs) and an applied alternating current (AC) magnetic field. Human MKN45 gastric cancer cells were implanted in the hind limb of Balb‐c/nu/nu mice. Various concentrations of docetaxel‐embedded DMLs were injected into the tumors and exposed to an AC magnetic field ( n = 6, each). For comparison with hyperthermia alone, magnetite‐loaded liposome (ML)‐injected tumors were exposed to an AC magnetic field. Furthermore, the results of DML without AC treatment and docetaxel diluted into PBS with AC treatment were also compared ( n = 10, each). Tumor surface temperature was maintained between 42 and 43°C. Tumor volume was reduced in the DML group with a docetaxel concentration > 56.8 μg/ml, while a docetaxel concentration > 568.5 μg/ml was required for tumor reduction without hyperthermia. Statistically significant differences in tumor volume and survival rate were observed between the DML group exposed to the magnetic field and the other groups. The tumor disappeared in 3 mice in the DML group exposed to the magnetic field; 2 mice survived over 6 months after treatment, whereas all mice of the other groups died by 15 weeks. Histologically, hyperthermia with DML damaged tumor cells and DML diffused homogeneously. To the best of our knowledge, this is the first report to show that hyperthermia using chemotherapeutic agent‐embedded magnetoliposomes has an anticancer effect. |
format |
Article in Journal/Newspaper |
author |
Yoshida, Motohira Watanabe, Yuji Sato, Mitsunori Maehara, Tsunehiro Aono, Hiromichi Naohara, Takashi Hirazawa, Hideyuki Horiuchi, Atsushi Yukumi, Shungo Sato, Koichi Nakagawa, Hiromichi Yamamoto, Yuji Sugishita, Hiroki Kawachi, Kanji |
spellingShingle |
Yoshida, Motohira Watanabe, Yuji Sato, Mitsunori Maehara, Tsunehiro Aono, Hiromichi Naohara, Takashi Hirazawa, Hideyuki Horiuchi, Atsushi Yukumi, Shungo Sato, Koichi Nakagawa, Hiromichi Yamamoto, Yuji Sugishita, Hiroki Kawachi, Kanji Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
author_facet |
Yoshida, Motohira Watanabe, Yuji Sato, Mitsunori Maehara, Tsunehiro Aono, Hiromichi Naohara, Takashi Hirazawa, Hideyuki Horiuchi, Atsushi Yukumi, Shungo Sato, Koichi Nakagawa, Hiromichi Yamamoto, Yuji Sugishita, Hiroki Kawachi, Kanji |
author_sort |
Yoshida, Motohira |
title |
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
title_short |
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
title_full |
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
title_fullStr |
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
title_full_unstemmed |
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
title_sort |
feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1002/ijc.24864 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.24864 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.24864 |
genre |
DML |
genre_facet |
DML |
op_source |
International Journal of Cancer volume 126, issue 8, page 1955-1965 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.24864 |
container_title |
International Journal of Cancer |
container_volume |
126 |
container_issue |
8 |
container_start_page |
1955 |
op_container_end_page |
1965 |
_version_ |
1802643655597490176 |