Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study
Abstract In this nested case‐referent study, we related plasma concentrations of vitamin B12 to the risk of colorectal cancer, taking into consideration prediagnostic plasma folate and total homocysteine concentrations. Subjects were 226 cases and double matched referents from the population‐based N...
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Online Access: | http://dx.doi.org/10.1002/ijc.23299 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.23299 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.23299 |
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crwiley:10.1002/ijc.23299 2024-06-02T08:12:12+00:00 Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study Dahlin, Anna M. Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Palmqvist, Richard 2008 http://dx.doi.org/10.1002/ijc.23299 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.23299 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.23299 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 122, issue 9, page 2057-2061 ISSN 0020-7136 1097-0215 journal-article 2008 crwiley https://doi.org/10.1002/ijc.23299 2024-05-03T11:31:46Z Abstract In this nested case‐referent study, we related plasma concentrations of vitamin B12 to the risk of colorectal cancer, taking into consideration prediagnostic plasma folate and total homocysteine concentrations. Subjects were 226 cases and double matched referents from the population‐based Northern Sweden Health and Disease Study. Follow‐up times from recruitment to diagnosis ranged from 0.1 to 12.7 years, with a median of 4.2 years. Plasma vitamin B12 concentrations were inversely associated with the risk of rectal cancer: univariate odds ratio for the highest versus lowest quintile 0.34 (95% confidence interval (95% CI) 0.13–0.83), p trend = 0.004. Risk estimates were attenuated slightly but remained statistically significant after adjustment for body mass index, current smoking, recreational and occupational physical activity, alcohol intake and prediagnostic plasma folate and total homocysteine concentrations: OR 0.30 (95% CI 0.08–0.99), p trend = 0.025. The corresponding univariate and fully adjusted odds ratios for colon cancer were 1.25 (CI 0.66–2.36), p trend = 0.185 and 1.42 (CI 0.67–3.05), p trend = 0.113, respectively. The observed over‐risk was attributable to left‐sided colon cancer. Interaction analyses including vitamin B12, folate and homocysteine were in line with the results for vitamin B12 alone. In conclusion, these results suggest that increasing levels of plasma vitamin B12, alone or together with other factors involved in one‐carbon metabolism, may reduce the risk of rectal cancer, whereas for colon cancer, the association appears to be less clear. © 2007 Wiley‐Liss, Inc. Article in Journal/Newspaper Northern Sweden Wiley Online Library International Journal of Cancer 122 9 2057 2061 |
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Abstract In this nested case‐referent study, we related plasma concentrations of vitamin B12 to the risk of colorectal cancer, taking into consideration prediagnostic plasma folate and total homocysteine concentrations. Subjects were 226 cases and double matched referents from the population‐based Northern Sweden Health and Disease Study. Follow‐up times from recruitment to diagnosis ranged from 0.1 to 12.7 years, with a median of 4.2 years. Plasma vitamin B12 concentrations were inversely associated with the risk of rectal cancer: univariate odds ratio for the highest versus lowest quintile 0.34 (95% confidence interval (95% CI) 0.13–0.83), p trend = 0.004. Risk estimates were attenuated slightly but remained statistically significant after adjustment for body mass index, current smoking, recreational and occupational physical activity, alcohol intake and prediagnostic plasma folate and total homocysteine concentrations: OR 0.30 (95% CI 0.08–0.99), p trend = 0.025. The corresponding univariate and fully adjusted odds ratios for colon cancer were 1.25 (CI 0.66–2.36), p trend = 0.185 and 1.42 (CI 0.67–3.05), p trend = 0.113, respectively. The observed over‐risk was attributable to left‐sided colon cancer. Interaction analyses including vitamin B12, folate and homocysteine were in line with the results for vitamin B12 alone. In conclusion, these results suggest that increasing levels of plasma vitamin B12, alone or together with other factors involved in one‐carbon metabolism, may reduce the risk of rectal cancer, whereas for colon cancer, the association appears to be less clear. © 2007 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Dahlin, Anna M. Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Palmqvist, Richard |
spellingShingle |
Dahlin, Anna M. Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Palmqvist, Richard Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
author_facet |
Dahlin, Anna M. Van Guelpen, Bethany Hultdin, Johan Johansson, Ingegerd Hallmans, Göran Palmqvist, Richard |
author_sort |
Dahlin, Anna M. |
title |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
title_short |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
title_full |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
title_fullStr |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
title_full_unstemmed |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case‐referent study |
title_sort |
plasma vitamin b12 concentrations and the risk of colorectal cancer: a nested case‐referent study |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1002/ijc.23299 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.23299 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.23299 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
International Journal of Cancer volume 122, issue 9, page 2057-2061 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.23299 |
container_title |
International Journal of Cancer |
container_volume |
122 |
container_issue |
9 |
container_start_page |
2057 |
op_container_end_page |
2061 |
_version_ |
1800758561795473408 |