Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors?
Abstract The aim of this study was to characterize the familial risk of colon and rectal cancer using 2 population‐based registries in Iceland, the Icelandic Cancer Registry and a genealogy database. The standardized incidence ratio (SIR) was used to estimate the risk among relatives of colorectal c...
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Online Access: | http://dx.doi.org/10.1002/ijc.21835 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21835 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21835 |
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crwiley:10.1002/ijc.21835 2024-06-02T08:08:36+00:00 Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? Stefansson, Tryggvi Moller, Pall H. Sigurdsson, Fridbjorn Steingrimsson, Eirikur Eldon, Bjarki Jónsson 2006 http://dx.doi.org/10.1002/ijc.21835 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21835 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21835 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 119, issue 2, page 304-308 ISSN 0020-7136 1097-0215 journal-article 2006 crwiley https://doi.org/10.1002/ijc.21835 2024-05-03T10:49:29Z Abstract The aim of this study was to characterize the familial risk of colon and rectal cancer using 2 population‐based registries in Iceland, the Icelandic Cancer Registry and a genealogy database. The standardized incidence ratio (SIR) was used to estimate the risk among relatives of colorectal cancer index cases diagnosed in Iceland over a 46‐year period (1955–2000). The 2,770 colorectal cancer patients had 23,272 first‐degree relatives. Among first‐degree relatives, there was an increased risk of both colon (SIR 1.47, 95% confidence interval (CI) 1.34–1.62) and rectal cancer (SIR 1.24, 95% CI 1.04–1.47). An increased risk of colon cancer was observed among siblings of colon cancer patients (SIR 2.03, 95% CI 1.76–2.33), whereas no such increase was observed for parents or offspring. Furthermore, the risk of rectal cancer was only increased among brothers (SIR 2.46 95% CI 1.46–3.89) of rectal cancer patients and not among their sisters (SIR 1.0 95% CI 0.40–2.06). The added risk of colon cancer among first‐degree relatives was independent of site of colon cancer in the proband. Our results confirm that family history of colorectal cancer is a risk factor for the disease. However, family history has a different association with colon cancer than with rectal cancer, suggesting that the 2 cancer types may have different etiologic factors. Our results have implications for colon and rectal cancer screening programs. © 2006 Wiley‐Liss, Inc. Article in Journal/Newspaper Iceland Wiley Online Library International Journal of Cancer 119 2 304 308 |
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English |
description |
Abstract The aim of this study was to characterize the familial risk of colon and rectal cancer using 2 population‐based registries in Iceland, the Icelandic Cancer Registry and a genealogy database. The standardized incidence ratio (SIR) was used to estimate the risk among relatives of colorectal cancer index cases diagnosed in Iceland over a 46‐year period (1955–2000). The 2,770 colorectal cancer patients had 23,272 first‐degree relatives. Among first‐degree relatives, there was an increased risk of both colon (SIR 1.47, 95% confidence interval (CI) 1.34–1.62) and rectal cancer (SIR 1.24, 95% CI 1.04–1.47). An increased risk of colon cancer was observed among siblings of colon cancer patients (SIR 2.03, 95% CI 1.76–2.33), whereas no such increase was observed for parents or offspring. Furthermore, the risk of rectal cancer was only increased among brothers (SIR 2.46 95% CI 1.46–3.89) of rectal cancer patients and not among their sisters (SIR 1.0 95% CI 0.40–2.06). The added risk of colon cancer among first‐degree relatives was independent of site of colon cancer in the proband. Our results confirm that family history of colorectal cancer is a risk factor for the disease. However, family history has a different association with colon cancer than with rectal cancer, suggesting that the 2 cancer types may have different etiologic factors. Our results have implications for colon and rectal cancer screening programs. © 2006 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Stefansson, Tryggvi Moller, Pall H. Sigurdsson, Fridbjorn Steingrimsson, Eirikur Eldon, Bjarki Jónsson |
spellingShingle |
Stefansson, Tryggvi Moller, Pall H. Sigurdsson, Fridbjorn Steingrimsson, Eirikur Eldon, Bjarki Jónsson Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
author_facet |
Stefansson, Tryggvi Moller, Pall H. Sigurdsson, Fridbjorn Steingrimsson, Eirikur Eldon, Bjarki Jónsson |
author_sort |
Stefansson, Tryggvi |
title |
Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
title_short |
Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
title_full |
Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
title_fullStr |
Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
title_full_unstemmed |
Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors? |
title_sort |
familial risk of colon and rectal cancer in iceland: evidence for different etiologic factors? |
publisher |
Wiley |
publishDate |
2006 |
url |
http://dx.doi.org/10.1002/ijc.21835 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21835 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21835 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
International Journal of Cancer volume 119, issue 2, page 304-308 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.21835 |
container_title |
International Journal of Cancer |
container_volume |
119 |
container_issue |
2 |
container_start_page |
304 |
op_container_end_page |
308 |
_version_ |
1800753909744009216 |