A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma
Abstract Persistent human papillomavirus (HPV) infection is an established cause of cervical cancer, but the role of other sexually transmitted agents, most notably Chlamydia trachomatis, has not been well defined. The women participating in the population‐based cervical cancer screening program in...
Published in: | International Journal of Cancer |
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Online Access: | http://dx.doi.org/10.1002/ijc.10639 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.10639 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.10639 |
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crwiley:10.1002/ijc.10639 2024-06-09T07:48:37+00:00 A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma Wallin, Keng‐Ling Wiklund, Fredrik Luostarinen, Tapio Ångström, Tord Anttila, Tarja Bergman, Frank Hallmans, Göran Ikäheimo, Irma Koskela, Pentti Lehtinen, Matti Stendahl, Ulf Paavonen, Jorma Dillner, Joakim Swedish Cancer Society Nordic Academy for Advanced Studies 2002 http://dx.doi.org/10.1002/ijc.10639 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.10639 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.10639 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Cancer volume 101, issue 4, page 371-374 ISSN 0020-7136 1097-0215 journal-article 2002 crwiley https://doi.org/10.1002/ijc.10639 2024-05-16T14:26:53Z Abstract Persistent human papillomavirus (HPV) infection is an established cause of cervical cancer, but the role of other sexually transmitted agents, most notably Chlamydia trachomatis, has not been well defined. The women participating in the population‐based cervical cancer screening program in Västerbotten county of Northern Sweden were followed up for up to 26 years to identify 118 women who developed cervical cancer after having had a normal Pap smear (on average 5.6 years later; range 0.5 months–26 years). As controls, we selected another 118 women who were matched by birth cohort, time‐point of sampling of the baseline normal smear and who had a normal smear at the time when the corresponding case was diagnosed with cancer. The Pap smears and cervical cancer biopsies were analyzed by PCR for C. trachomatis DNA and for HPV DNA. At baseline, C. trachomatis DNA was present in 8% of cases but not among any one of the controls. The relative risk for cervical cancer associated with past C. trachomatis infection, adjusted for concomitant HPV DNA positivity, was 17.1 (95% CI 2.6–∞).The presence of C. trachomatis and of HPV were not interrelated. Whereas C. trachomatis was primarily found in specimens taken many years before cancer diagnosis, HPV DNA was associated with a short lag time before cancer diagnosis. Whereas most women who were HPV DNA‐positive in the prediagnostic smear were also positive for the same virus in the cervical cancer biopsy, none of the women were positive for C. trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer. © 2002 Wiley‐Liss, Inc. Article in Journal/Newspaper Northern Sweden Wiley Online Library International Journal of Cancer 101 4 371 374 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract Persistent human papillomavirus (HPV) infection is an established cause of cervical cancer, but the role of other sexually transmitted agents, most notably Chlamydia trachomatis, has not been well defined. The women participating in the population‐based cervical cancer screening program in Västerbotten county of Northern Sweden were followed up for up to 26 years to identify 118 women who developed cervical cancer after having had a normal Pap smear (on average 5.6 years later; range 0.5 months–26 years). As controls, we selected another 118 women who were matched by birth cohort, time‐point of sampling of the baseline normal smear and who had a normal smear at the time when the corresponding case was diagnosed with cancer. The Pap smears and cervical cancer biopsies were analyzed by PCR for C. trachomatis DNA and for HPV DNA. At baseline, C. trachomatis DNA was present in 8% of cases but not among any one of the controls. The relative risk for cervical cancer associated with past C. trachomatis infection, adjusted for concomitant HPV DNA positivity, was 17.1 (95% CI 2.6–∞).The presence of C. trachomatis and of HPV were not interrelated. Whereas C. trachomatis was primarily found in specimens taken many years before cancer diagnosis, HPV DNA was associated with a short lag time before cancer diagnosis. Whereas most women who were HPV DNA‐positive in the prediagnostic smear were also positive for the same virus in the cervical cancer biopsy, none of the women were positive for C. trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer. © 2002 Wiley‐Liss, Inc. |
author2 |
Swedish Cancer Society Nordic Academy for Advanced Studies |
format |
Article in Journal/Newspaper |
author |
Wallin, Keng‐Ling Wiklund, Fredrik Luostarinen, Tapio Ångström, Tord Anttila, Tarja Bergman, Frank Hallmans, Göran Ikäheimo, Irma Koskela, Pentti Lehtinen, Matti Stendahl, Ulf Paavonen, Jorma Dillner, Joakim |
spellingShingle |
Wallin, Keng‐Ling Wiklund, Fredrik Luostarinen, Tapio Ångström, Tord Anttila, Tarja Bergman, Frank Hallmans, Göran Ikäheimo, Irma Koskela, Pentti Lehtinen, Matti Stendahl, Ulf Paavonen, Jorma Dillner, Joakim A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
author_facet |
Wallin, Keng‐Ling Wiklund, Fredrik Luostarinen, Tapio Ångström, Tord Anttila, Tarja Bergman, Frank Hallmans, Göran Ikäheimo, Irma Koskela, Pentti Lehtinen, Matti Stendahl, Ulf Paavonen, Jorma Dillner, Joakim |
author_sort |
Wallin, Keng‐Ling |
title |
A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
title_short |
A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
title_full |
A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
title_fullStr |
A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
title_full_unstemmed |
A population‐based prospective study of Chlamydia trachomatis infection and cervical carcinoma |
title_sort |
population‐based prospective study of chlamydia trachomatis infection and cervical carcinoma |
publisher |
Wiley |
publishDate |
2002 |
url |
http://dx.doi.org/10.1002/ijc.10639 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.10639 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.10639 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
International Journal of Cancer volume 101, issue 4, page 371-374 ISSN 0020-7136 1097-0215 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ijc.10639 |
container_title |
International Journal of Cancer |
container_volume |
101 |
container_issue |
4 |
container_start_page |
371 |
op_container_end_page |
374 |
_version_ |
1801380411526348800 |