Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives
Abstract A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivit...
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crwiley:10.1002/hlca.19960790408 2024-06-02T07:58:14+00:00 Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives Baldessari, Alicia Bruttomesso, Andrea C. Gros, Eduardo G. 1996 http://dx.doi.org/10.1002/hlca.19960790408 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhlca.19960790408 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hlca.19960790408 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Helvetica Chimica Acta volume 79, issue 4, page 999-1004 ISSN 0018-019X 1522-2675 journal-article 1996 crwiley https://doi.org/10.1002/hlca.19960790408 2024-05-03T10:43:58Z Abstract A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β‐ or the 17β‐acetyl group (see Table 2 ). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Helvetica Chimica Acta 79 4 999 1004 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β‐ or the 17β‐acetyl group (see Table 2 ). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given. |
format |
Article in Journal/Newspaper |
author |
Baldessari, Alicia Bruttomesso, Andrea C. Gros, Eduardo G. |
spellingShingle |
Baldessari, Alicia Bruttomesso, Andrea C. Gros, Eduardo G. Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
author_facet |
Baldessari, Alicia Bruttomesso, Andrea C. Gros, Eduardo G. |
author_sort |
Baldessari, Alicia |
title |
Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
title_short |
Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
title_full |
Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
title_fullStr |
Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
title_full_unstemmed |
Lipase‐Catalysed Regioselective Deacetylation of androstane derivatives |
title_sort |
lipase‐catalysed regioselective deacetylation of androstane derivatives |
publisher |
Wiley |
publishDate |
1996 |
url |
http://dx.doi.org/10.1002/hlca.19960790408 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhlca.19960790408 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hlca.19960790408 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Helvetica Chimica Acta volume 79, issue 4, page 999-1004 ISSN 0018-019X 1522-2675 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/hlca.19960790408 |
container_title |
Helvetica Chimica Acta |
container_volume |
79 |
container_issue |
4 |
container_start_page |
999 |
op_container_end_page |
1004 |
_version_ |
1800741525089419264 |