Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world
Abstract Apolipoprotein E (apoE) phenotypes were determined in a random sample of 466 Danish men born in 1948. The frequencies of the common alleles of the apoE gene were (with 95% confidence intervals) ϵ2 = 0.085 (0.068–0.105), ϵ3 = 0.741 (0.712–0.769), and ϵ4 = 0.174 (0.150–0.200). These frequenci...
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crwiley:10.1002/gepi.1370090302 2024-10-13T14:08:20+00:00 Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world Gerdes, Lars Ulrik Klausen, Ib Christian Sihm, Inger Faergeman, Ole Vogler, G. P. 1992 http://dx.doi.org/10.1002/gepi.1370090302 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgepi.1370090302 https://onlinelibrary.wiley.com/doi/pdf/10.1002/gepi.1370090302 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Genetic Epidemiology volume 9, issue 3, page 155-167 ISSN 0741-0395 1098-2272 journal-article 1992 crwiley https://doi.org/10.1002/gepi.1370090302 2024-09-17T04:51:24Z Abstract Apolipoprotein E (apoE) phenotypes were determined in a random sample of 466 Danish men born in 1948. The frequencies of the common alleles of the apoE gene were (with 95% confidence intervals) ϵ2 = 0.085 (0.068–0.105), ϵ3 = 0.741 (0.712–0.769), and ϵ4 = 0.174 (0.150–0.200). These frequencies were compared to findings in 45 other study populations around the world (n > 100). The Danish population was found to cluster with populations from Iceland, Norway, Iceland, Scotland, the Netherlands, Germany, France (Paris), and Caucasian populations in Canada and the USA. The compiled data further show that dissimilarities in apoE allele frequencies among Caucasian populations are comparable to dissimilarities between some Caucasian and Asian populations. Notably, the frequency of ϵ4 appears to be higher in northern regions of Europe (the Nordic countries, Scotland, Germany, and the Netherlands) than in southern regions (Switzerland, Tyrol, France [Nancy], Italy, and Spain). © 1992 Wiley‐Liss, Inc. Article in Journal/Newspaper Iceland Wiley Online Library Canada Norway Genetic Epidemiology 9 3 155 167 |
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English |
description |
Abstract Apolipoprotein E (apoE) phenotypes were determined in a random sample of 466 Danish men born in 1948. The frequencies of the common alleles of the apoE gene were (with 95% confidence intervals) ϵ2 = 0.085 (0.068–0.105), ϵ3 = 0.741 (0.712–0.769), and ϵ4 = 0.174 (0.150–0.200). These frequencies were compared to findings in 45 other study populations around the world (n > 100). The Danish population was found to cluster with populations from Iceland, Norway, Iceland, Scotland, the Netherlands, Germany, France (Paris), and Caucasian populations in Canada and the USA. The compiled data further show that dissimilarities in apoE allele frequencies among Caucasian populations are comparable to dissimilarities between some Caucasian and Asian populations. Notably, the frequency of ϵ4 appears to be higher in northern regions of Europe (the Nordic countries, Scotland, Germany, and the Netherlands) than in southern regions (Switzerland, Tyrol, France [Nancy], Italy, and Spain). © 1992 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Gerdes, Lars Ulrik Klausen, Ib Christian Sihm, Inger Faergeman, Ole Vogler, G. P. |
spellingShingle |
Gerdes, Lars Ulrik Klausen, Ib Christian Sihm, Inger Faergeman, Ole Vogler, G. P. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
author_facet |
Gerdes, Lars Ulrik Klausen, Ib Christian Sihm, Inger Faergeman, Ole Vogler, G. P. |
author_sort |
Gerdes, Lars Ulrik |
title |
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
title_short |
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
title_full |
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
title_fullStr |
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
title_full_unstemmed |
Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world |
title_sort |
apolipoprotein e polymorphism in a danish population compared to findings in 45 other study populations around the world |
publisher |
Wiley |
publishDate |
1992 |
url |
http://dx.doi.org/10.1002/gepi.1370090302 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgepi.1370090302 https://onlinelibrary.wiley.com/doi/pdf/10.1002/gepi.1370090302 |
geographic |
Canada Norway |
geographic_facet |
Canada Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Genetic Epidemiology volume 9, issue 3, page 155-167 ISSN 0741-0395 1098-2272 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/gepi.1370090302 |
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Genetic Epidemiology |
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9 |
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3 |
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155 |
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167 |
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1812815019568529408 |