Affective disorder not linked to HLA
Abstract These analyses focused on the relationship of affective disorders to HLA. The sample of 86 previously unpublished families from Ontario and 10 unpublished pedigrees from Newfoundland, as well as the original Weitkamp et al. [1981] sample of 20 families, the samples provided by NIMH [Goldin...
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crwiley:10.1002/gepi.1370060152 2024-06-02T08:10:43+00:00 Affective disorder not linked to HLA Price, R. Arlen 1989 http://dx.doi.org/10.1002/gepi.1370060152 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgepi.1370060152 https://onlinelibrary.wiley.com/doi/pdf/10.1002/gepi.1370060152 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Genetic Epidemiology volume 6, issue 1, page 299-304 ISSN 0741-0395 1098-2272 journal-article 1989 crwiley https://doi.org/10.1002/gepi.1370060152 2024-05-03T11:49:28Z Abstract These analyses focused on the relationship of affective disorders to HLA. The sample of 86 previously unpublished families from Ontario and 10 unpublished pedigrees from Newfoundland, as well as the original Weitkamp et al. [1981] sample of 20 families, the samples provided by NIMH [Goldin et al., 1982] (18 families), and Egeland et al. [1987] (2 large pedigrees), were examined using sib pair methods as well as standard linkage analysis of the full pedigrees. A variety of genetic models were examined. There was no evidence for linkage from any of the samples based on either analytic approach or for any genetic model. Groups of sibling pairs concordant for affective illness, concordant for being well, or discordant for affective illness did not differ in the proportion of genes identical by descent. No group differed significantly from 50%. From the analysis of full pedigrees, linkage to HLA could be excluded to a distance of approximately 20 to 25 centimorgans. There was no evidence for linkage heterogeneity. These results argue against linkage of affective disorder to HLA. Article in Journal/Newspaper Newfoundland Wiley Online Library Goldin ENVELOPE(23.607,23.607,69.345,69.345) Genetic Epidemiology 6 1 299 304 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract These analyses focused on the relationship of affective disorders to HLA. The sample of 86 previously unpublished families from Ontario and 10 unpublished pedigrees from Newfoundland, as well as the original Weitkamp et al. [1981] sample of 20 families, the samples provided by NIMH [Goldin et al., 1982] (18 families), and Egeland et al. [1987] (2 large pedigrees), were examined using sib pair methods as well as standard linkage analysis of the full pedigrees. A variety of genetic models were examined. There was no evidence for linkage from any of the samples based on either analytic approach or for any genetic model. Groups of sibling pairs concordant for affective illness, concordant for being well, or discordant for affective illness did not differ in the proportion of genes identical by descent. No group differed significantly from 50%. From the analysis of full pedigrees, linkage to HLA could be excluded to a distance of approximately 20 to 25 centimorgans. There was no evidence for linkage heterogeneity. These results argue against linkage of affective disorder to HLA. |
format |
Article in Journal/Newspaper |
author |
Price, R. Arlen |
spellingShingle |
Price, R. Arlen Affective disorder not linked to HLA |
author_facet |
Price, R. Arlen |
author_sort |
Price, R. Arlen |
title |
Affective disorder not linked to HLA |
title_short |
Affective disorder not linked to HLA |
title_full |
Affective disorder not linked to HLA |
title_fullStr |
Affective disorder not linked to HLA |
title_full_unstemmed |
Affective disorder not linked to HLA |
title_sort |
affective disorder not linked to hla |
publisher |
Wiley |
publishDate |
1989 |
url |
http://dx.doi.org/10.1002/gepi.1370060152 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgepi.1370060152 https://onlinelibrary.wiley.com/doi/pdf/10.1002/gepi.1370060152 |
long_lat |
ENVELOPE(23.607,23.607,69.345,69.345) |
geographic |
Goldin |
geographic_facet |
Goldin |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Genetic Epidemiology volume 6, issue 1, page 299-304 ISSN 0741-0395 1098-2272 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/gepi.1370060152 |
container_title |
Genetic Epidemiology |
container_volume |
6 |
container_issue |
1 |
container_start_page |
299 |
op_container_end_page |
304 |
_version_ |
1800756633902514176 |