Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures
Abstract The disposition and depuration of lindane (γ‐hexachlorocyclohexane [HCH]) and polychlorinated biphenyl (PCB)‐110 (2,3,3′,4′,6‐pentachlorobiphenyl), orally administered to cod ( Gadus morhua ) and bullrout ( Myoxocephalus scorpius ), were investigated using whole‐body autoradiography, liquid...
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crwiley:10.1002/etc.5620201033 2024-06-02T08:06:54+00:00 Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures Ruus, Anders Skaare, Janneche Utne Ingebrigtsen, Kristian 2001 http://dx.doi.org/10.1002/etc.5620201033 http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.5620201033 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5620201033 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 20, issue 10, page 2377-2382 ISSN 0730-7268 1552-8618 journal-article 2001 crwiley https://doi.org/10.1002/etc.5620201033 2024-05-03T10:51:17Z Abstract The disposition and depuration of lindane (γ‐hexachlorocyclohexane [HCH]) and polychlorinated biphenyl (PCB)‐110 (2,3,3′,4′,6‐pentachlorobiphenyl), orally administered to cod ( Gadus morhua ) and bullrout ( Myoxocephalus scorpius ), were investigated using whole‐body autoradiography, liquid scintillation counting, and gas chromatography with electron‐capture detection. Both γ‐HCH and PCB‐110 were distributed mainly to lipid‐rich organs after absorption from the gastrointestinal tract of cod and bullrout. Compared to bullrout liver, the cod liver contained higher concentrations of both compounds, reflecting the distribution of fat in the two species. In both species, the depuration time for γ‐HCH was shorter than for PCB‐110. Both substances were excreted via bile and urine, largely as water‐soluble metabolites. The water‐soluble bile metabolites, together with PCB‐110 metabolites associated to endogenous macromolecules, strongly indicate that this compound is metabolized in both species. Article in Journal/Newspaper Gadus morhua Wiley Online Library Environmental Toxicology and Chemistry 20 10 2377 2382 |
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Wiley Online Library |
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language |
English |
description |
Abstract The disposition and depuration of lindane (γ‐hexachlorocyclohexane [HCH]) and polychlorinated biphenyl (PCB)‐110 (2,3,3′,4′,6‐pentachlorobiphenyl), orally administered to cod ( Gadus morhua ) and bullrout ( Myoxocephalus scorpius ), were investigated using whole‐body autoradiography, liquid scintillation counting, and gas chromatography with electron‐capture detection. Both γ‐HCH and PCB‐110 were distributed mainly to lipid‐rich organs after absorption from the gastrointestinal tract of cod and bullrout. Compared to bullrout liver, the cod liver contained higher concentrations of both compounds, reflecting the distribution of fat in the two species. In both species, the depuration time for γ‐HCH was shorter than for PCB‐110. Both substances were excreted via bile and urine, largely as water‐soluble metabolites. The water‐soluble bile metabolites, together with PCB‐110 metabolites associated to endogenous macromolecules, strongly indicate that this compound is metabolized in both species. |
format |
Article in Journal/Newspaper |
author |
Ruus, Anders Skaare, Janneche Utne Ingebrigtsen, Kristian |
spellingShingle |
Ruus, Anders Skaare, Janneche Utne Ingebrigtsen, Kristian Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
author_facet |
Ruus, Anders Skaare, Janneche Utne Ingebrigtsen, Kristian |
author_sort |
Ruus, Anders |
title |
Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
title_short |
Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
title_full |
Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
title_fullStr |
Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
title_full_unstemmed |
Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( Gadus morhua) and bullrout ( Myoxocephalus scorpius) after single oral exposures |
title_sort |
disposition and depuration of lindane (γ‐hch) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod ( gadus morhua) and bullrout ( myoxocephalus scorpius) after single oral exposures |
publisher |
Wiley |
publishDate |
2001 |
url |
http://dx.doi.org/10.1002/etc.5620201033 http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.5620201033 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5620201033 |
genre |
Gadus morhua |
genre_facet |
Gadus morhua |
op_source |
Environmental Toxicology and Chemistry volume 20, issue 10, page 2377-2382 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/etc.5620201033 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
20 |
container_issue |
10 |
container_start_page |
2377 |
op_container_end_page |
2382 |
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1800751899007254528 |