Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals
Abstract A physiologically based pharmacokinetic model is developed that describes the uptake and release of a hydrophobic organic chemical by a marine mammal over its entire lifetime, i.e., from birth to death. This model is applied to polychlorinated biphenyls (PCBs) in the beluga whale (Delphinap...
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crwiley:10.1002/etc.5620181132 2024-06-23T07:51:42+00:00 Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals Hickie, Brendan E. Mackay, Donald de Koning, Jason 1999 http://dx.doi.org/10.1002/etc.5620181132 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.5620181132 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5620181132 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 18, issue 11, page 2622-2633 ISSN 0730-7268 1552-8618 journal-article 1999 crwiley https://doi.org/10.1002/etc.5620181132 2024-06-04T06:37:33Z Abstract A physiologically based pharmacokinetic model is developed that describes the uptake and release of a hydrophobic organic chemical by a marine mammal over its entire lifetime, i.e., from birth to death. This model is applied to polychlorinated biphenyls (PCBs) in the beluga whale (Delphinapterus leucas) . The processes treated are growth; uptake from food, milk, and air; disposition of the chemical among arterial and venous blood, liver, muscle, blubber, and rapidly perfused tissues; and losses by metabolism, release in exhaled air, and by egestion. A separate model is developed for females, which includes pregnancy, birth, and lactation. Food consumption is deduced from size, growth, and from activity‐dependent bioenergetic data. The results obtained by simulating continuous PCB exposure over a 30‐year period are in accordance with reported concentrations and show the importance of milk transfer to both mother and progeny and the tendency for continued accumulation over the animal's lifetime. Implications of the results are discussed, especially the need for improved data on diets, gut absorption characteristics, and various physiological parameters used in the model. Article in Journal/Newspaper Beluga Beluga whale Beluga* Delphinapterus leucas Wiley Online Library Environmental Toxicology and Chemistry 18 11 2622 2633 |
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English |
description |
Abstract A physiologically based pharmacokinetic model is developed that describes the uptake and release of a hydrophobic organic chemical by a marine mammal over its entire lifetime, i.e., from birth to death. This model is applied to polychlorinated biphenyls (PCBs) in the beluga whale (Delphinapterus leucas) . The processes treated are growth; uptake from food, milk, and air; disposition of the chemical among arterial and venous blood, liver, muscle, blubber, and rapidly perfused tissues; and losses by metabolism, release in exhaled air, and by egestion. A separate model is developed for females, which includes pregnancy, birth, and lactation. Food consumption is deduced from size, growth, and from activity‐dependent bioenergetic data. The results obtained by simulating continuous PCB exposure over a 30‐year period are in accordance with reported concentrations and show the importance of milk transfer to both mother and progeny and the tendency for continued accumulation over the animal's lifetime. Implications of the results are discussed, especially the need for improved data on diets, gut absorption characteristics, and various physiological parameters used in the model. |
format |
Article in Journal/Newspaper |
author |
Hickie, Brendan E. Mackay, Donald de Koning, Jason |
spellingShingle |
Hickie, Brendan E. Mackay, Donald de Koning, Jason Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
author_facet |
Hickie, Brendan E. Mackay, Donald de Koning, Jason |
author_sort |
Hickie, Brendan E. |
title |
Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
title_short |
Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
title_full |
Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
title_fullStr |
Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
title_full_unstemmed |
Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
title_sort |
lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals |
publisher |
Wiley |
publishDate |
1999 |
url |
http://dx.doi.org/10.1002/etc.5620181132 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.5620181132 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5620181132 |
genre |
Beluga Beluga whale Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga whale Beluga* Delphinapterus leucas |
op_source |
Environmental Toxicology and Chemistry volume 18, issue 11, page 2622-2633 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/etc.5620181132 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
18 |
container_issue |
11 |
container_start_page |
2622 |
op_container_end_page |
2633 |
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1802642817242103808 |