Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals
Abstract The present study assessed and compared the oxidative and reductive biotransformation of brominated flame retardants, including established polybrominated diphenyl ethers (PBDEs) and emerging decabromodiphenyl ethane (DBDPE) using an in vitro system based on liver microsomes from various ar...
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crwiley:10.1002/etc.535 2024-09-15T17:59:03+00:00 Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals McKinney, Melissa A. Dietz, Rune Sonne, Christian De Guise, Sylvain Skirnisson, Karl Karlsson, Karl Steingrímsson, Egill Letcher, Robert J. 2011 http://dx.doi.org/10.1002/etc.535 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.535 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.535 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 30, issue 7, page 1506-1514 ISSN 0730-7268 1552-8618 journal-article 2011 crwiley https://doi.org/10.1002/etc.535 2024-08-30T04:12:43Z Abstract The present study assessed and compared the oxidative and reductive biotransformation of brominated flame retardants, including established polybrominated diphenyl ethers (PBDEs) and emerging decabromodiphenyl ethane (DBDPE) using an in vitro system based on liver microsomes from various arctic marine‐feeding mammals: polar bear ( Ursus maritimus ), beluga whale ( Delphinapterus leucas ), and ringed seal ( Pusa hispida ), and in laboratory rat as a mammalian model species. Greater depletion of fully brominated BDE209 (14–25% of 30 pmol) and DBDPE (44–74% of 90 pmol) occurred in individuals from all species relative to depletion of lower brominated PBDEs (BDEs 99, 100, and 154; 0–3% of 30 pmol). No evidence of simply debrominated metabolites was observed. Investigation of phenolic metabolites in rat and polar bear revealed formation of two phenolic, likely multiply debrominated, DBDPE metabolites in polar bear and one phenolic BDE154 metabolite in polar bear and rat microsomes. For BDE209 and DBDPE, observed metabolite concentrations were low to nondetectable, despite substantial parent depletion. These findings suggested possible underestimation of the ecosystem burden of total‐BDE209, as well as its transformation products, and a need for research to identify and characterize the persistence and toxicity of major BDE209 metabolites. Similar cause for concern may exist regarding DBDPE, given similarities of physicochemical and environmental behavior to BDE209, current evidence of biotransformation, and increasing use of DBDPE as a replacement for BDE209. Environ. Toxicol. Chem. 2011; 30:1506–1514. © 2011 SETAC Article in Journal/Newspaper Beluga Beluga whale Beluga* Delphinapterus leucas Pusa hispida ringed seal Ursus maritimus Wiley Online Library Environmental Toxicology and Chemistry 30 7 1506 1514 |
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Open Polar |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract The present study assessed and compared the oxidative and reductive biotransformation of brominated flame retardants, including established polybrominated diphenyl ethers (PBDEs) and emerging decabromodiphenyl ethane (DBDPE) using an in vitro system based on liver microsomes from various arctic marine‐feeding mammals: polar bear ( Ursus maritimus ), beluga whale ( Delphinapterus leucas ), and ringed seal ( Pusa hispida ), and in laboratory rat as a mammalian model species. Greater depletion of fully brominated BDE209 (14–25% of 30 pmol) and DBDPE (44–74% of 90 pmol) occurred in individuals from all species relative to depletion of lower brominated PBDEs (BDEs 99, 100, and 154; 0–3% of 30 pmol). No evidence of simply debrominated metabolites was observed. Investigation of phenolic metabolites in rat and polar bear revealed formation of two phenolic, likely multiply debrominated, DBDPE metabolites in polar bear and one phenolic BDE154 metabolite in polar bear and rat microsomes. For BDE209 and DBDPE, observed metabolite concentrations were low to nondetectable, despite substantial parent depletion. These findings suggested possible underestimation of the ecosystem burden of total‐BDE209, as well as its transformation products, and a need for research to identify and characterize the persistence and toxicity of major BDE209 metabolites. Similar cause for concern may exist regarding DBDPE, given similarities of physicochemical and environmental behavior to BDE209, current evidence of biotransformation, and increasing use of DBDPE as a replacement for BDE209. Environ. Toxicol. Chem. 2011; 30:1506–1514. © 2011 SETAC |
format |
Article in Journal/Newspaper |
author |
McKinney, Melissa A. Dietz, Rune Sonne, Christian De Guise, Sylvain Skirnisson, Karl Karlsson, Karl Steingrímsson, Egill Letcher, Robert J. |
spellingShingle |
McKinney, Melissa A. Dietz, Rune Sonne, Christian De Guise, Sylvain Skirnisson, Karl Karlsson, Karl Steingrímsson, Egill Letcher, Robert J. Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
author_facet |
McKinney, Melissa A. Dietz, Rune Sonne, Christian De Guise, Sylvain Skirnisson, Karl Karlsson, Karl Steingrímsson, Egill Letcher, Robert J. |
author_sort |
McKinney, Melissa A. |
title |
Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
title_short |
Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
title_full |
Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
title_fullStr |
Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
title_full_unstemmed |
Comparative hepatic microsomal biotransformation of selected PBDEs, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in Arctic marine‐feeding mammals |
title_sort |
comparative hepatic microsomal biotransformation of selected pbdes, including decabromodiphenyl ether, and decabromodiphenyl ethane flame retardants in arctic marine‐feeding mammals |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1002/etc.535 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.535 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.535 |
genre |
Beluga Beluga whale Beluga* Delphinapterus leucas Pusa hispida ringed seal Ursus maritimus |
genre_facet |
Beluga Beluga whale Beluga* Delphinapterus leucas Pusa hispida ringed seal Ursus maritimus |
op_source |
Environmental Toxicology and Chemistry volume 30, issue 7, page 1506-1514 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/etc.535 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
30 |
container_issue |
7 |
container_start_page |
1506 |
op_container_end_page |
1514 |
_version_ |
1810435994284982272 |