Polycyclic Aromatic Hydrocarbons Alter the Hepatic Expression of Genes Involved in Sanderling ( Calidris alba) Pre‐migratory Fueling
Abstract Polycyclic aromatic hydrocarbons (PAHs) impaired pre‐migratory fueling in 49 orally dosed Sanderling ( Calidris alba ). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 µg total P...
Published in: | Environmental Toxicology and Chemistry |
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Main Authors: | , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2021
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/etc.5056 https://onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5056 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/etc.5056 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5056 |
Summary: | Abstract Polycyclic aromatic hydrocarbons (PAHs) impaired pre‐migratory fueling in 49 orally dosed Sanderling ( Calidris alba ). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 µg total PAH [tPAH]/kg body wt/day), PAH exposure decreased liver basic fatty acid binding protein 1 ( Lbfabp ) and hepatic lipase ( Lipc ) expression. The present study reveals candidate molecular‐level pathways for observed avian pre‐migratory refueling impairment. Environ Toxicol Chem 2021;40:1981–1989. © 2021 SETAC |
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