Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil
Abstract The 2 most abundant polycyclic aromatic hydrocarbons (PAHs) measured in Deepwater Horizon crude oil, naphthalene and phenanthrene, and their associated homologs have both been shown to be acutely toxic in fish. Although fish have a relatively high metabolic capacity for PAHs, hydroxylated P...
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crwiley:10.1002/etc.3898 2024-04-21T08:10:47+00:00 Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil Pulster, Erin L. Main, Kevan Wetzel, Dana Murawski, Steve Gulf of Mexico Research Initiative 2017 http://dx.doi.org/10.1002/etc.3898 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.3898 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.3898 en eng Wiley http://creativecommons.org/licenses/by-nc/4.0/ Environmental Toxicology and Chemistry volume 36, issue 11, page 3168-3176 ISSN 0730-7268 1552-8618 Health, Toxicology and Mutagenesis Environmental Chemistry journal-article 2017 crwiley https://doi.org/10.1002/etc.3898 2024-03-26T09:15:49Z Abstract The 2 most abundant polycyclic aromatic hydrocarbons (PAHs) measured in Deepwater Horizon crude oil, naphthalene and phenanthrene, and their associated homologs have both been shown to be acutely toxic in fish. Although fish have a relatively high metabolic capacity for PAHs, hydroxylated PAH (OH‐PAH) derivatives formed during the initial metabolic response can negatively impact the health of fish. Species‐specific metabolism of naphthalene and phenanthrene was evaluated in 3 marine teleosts, red drum ( Scianops ocellatus ), Florida pompano ( Trachinotus carolinus ), and southern flounder ( Paralichthys lethostigma ). Fish were exposed to Deepwater Horizon crude oil by intraperitoneal injections at time 0 and 48 h, with bile sampling events at 24 and 72 h post injection. The data suggested metabolic induction in Florida pompano and red drum, whereas southern flounder may have demonstrated metabolic fatigue. By 24 h post injection, overall profiles of red drum and southern flounder were dominated by hydroxylated phenanthrene metabolites; conversely, the Florida pompano profiles were dominated by monohydroxylated naphthalenes. In addition, Florida pompano had faster overall relative biotransformation rates, suggesting their potential decreased susceptibility to adverse effects. Red drum and southern flounder had much lower relative biotransformation rates, indicating their probable susceptibility to adverse outcomes after naphthalene and phenanthrene exposures. To our knowledge, the present study is the first to investigate monohydroxylated PAHs in fish exposed to Deepwater Horizon oil. Environ Toxicol Chem 2017;36:3168–3176. © 2017 © 2017 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. Article in Journal/Newspaper Red drum Wiley Online Library Environmental Toxicology and Chemistry 36 11 3168 3176 |
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Wiley Online Library |
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language |
English |
topic |
Health, Toxicology and Mutagenesis Environmental Chemistry |
spellingShingle |
Health, Toxicology and Mutagenesis Environmental Chemistry Pulster, Erin L. Main, Kevan Wetzel, Dana Murawski, Steve Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
topic_facet |
Health, Toxicology and Mutagenesis Environmental Chemistry |
description |
Abstract The 2 most abundant polycyclic aromatic hydrocarbons (PAHs) measured in Deepwater Horizon crude oil, naphthalene and phenanthrene, and their associated homologs have both been shown to be acutely toxic in fish. Although fish have a relatively high metabolic capacity for PAHs, hydroxylated PAH (OH‐PAH) derivatives formed during the initial metabolic response can negatively impact the health of fish. Species‐specific metabolism of naphthalene and phenanthrene was evaluated in 3 marine teleosts, red drum ( Scianops ocellatus ), Florida pompano ( Trachinotus carolinus ), and southern flounder ( Paralichthys lethostigma ). Fish were exposed to Deepwater Horizon crude oil by intraperitoneal injections at time 0 and 48 h, with bile sampling events at 24 and 72 h post injection. The data suggested metabolic induction in Florida pompano and red drum, whereas southern flounder may have demonstrated metabolic fatigue. By 24 h post injection, overall profiles of red drum and southern flounder were dominated by hydroxylated phenanthrene metabolites; conversely, the Florida pompano profiles were dominated by monohydroxylated naphthalenes. In addition, Florida pompano had faster overall relative biotransformation rates, suggesting their potential decreased susceptibility to adverse effects. Red drum and southern flounder had much lower relative biotransformation rates, indicating their probable susceptibility to adverse outcomes after naphthalene and phenanthrene exposures. To our knowledge, the present study is the first to investigate monohydroxylated PAHs in fish exposed to Deepwater Horizon oil. Environ Toxicol Chem 2017;36:3168–3176. © 2017 © 2017 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. |
author2 |
Gulf of Mexico Research Initiative |
format |
Article in Journal/Newspaper |
author |
Pulster, Erin L. Main, Kevan Wetzel, Dana Murawski, Steve |
author_facet |
Pulster, Erin L. Main, Kevan Wetzel, Dana Murawski, Steve |
author_sort |
Pulster, Erin L. |
title |
Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
title_short |
Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
title_full |
Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
title_fullStr |
Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
title_full_unstemmed |
Species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil |
title_sort |
species‐specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to deepwater horizon crude oil |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1002/etc.3898 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.3898 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.3898 |
genre |
Red drum |
genre_facet |
Red drum |
op_source |
Environmental Toxicology and Chemistry volume 36, issue 11, page 3168-3176 ISSN 0730-7268 1552-8618 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1002/etc.3898 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
36 |
container_issue |
11 |
container_start_page |
3168 |
op_container_end_page |
3176 |
_version_ |
1796952371427803136 |