In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus)
Abstract Mercury (Hg) has been detected in polar bear brain tissue, but its biological effects are not well known. Relationships between Hg concentrations and neurochemical enzyme activities and receptor binding were assessed in the cerebellum, frontal lobes, and occipital lobes of 24 polar bears co...
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crwiley:10.1002/etc.2685 2024-06-02T08:15:41+00:00 In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) Krey, Anke Kwan, Michael Chan, Hing Man Natural Sciences and Engineering Research Council of Canada ArcticNet Canada Research Chairs 2014 http://dx.doi.org/10.1002/etc.2685 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.2685 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.2685 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 33, issue 11, page 2463-2471 ISSN 0730-7268 1552-8618 journal-article 2014 crwiley https://doi.org/10.1002/etc.2685 2024-05-03T10:55:36Z Abstract Mercury (Hg) has been detected in polar bear brain tissue, but its biological effects are not well known. Relationships between Hg concentrations and neurochemical enzyme activities and receptor binding were assessed in the cerebellum, frontal lobes, and occipital lobes of 24 polar bears collected from Nunavik (Northern Quebec), Canada. The concentration–response relationship was further studied with in vitro experiments using pooled brain homogenate of 12 randomly chosen bears. In environmentally exposed brain samples, there was no correlative relationship between Hg concentration and cholinesterase (ChE) activity or muscarinic acetylcholine receptor (mAChR) binding in any of the 3 brain regions. Monoamine oxidase (MAO) activity in the occipital lobe showed a negative correlative relationship with total Hg concentration. In vitro experiments, however, demonstrated that Hg (mercuric chloride and methylmercury chloride) can inhibit ChE and MAO activities and muscarinic mAChR binding. These results show that Hg can alter neurobiochemical parameters but the current environmental Hg exposure level does have an effect on the neurochemistry of polar bears from northern Canada. Environ Toxicol Chem 2014;33:2463–2471 . © 2014 SETAC Article in Journal/Newspaper Ursus maritimus Nunavik Wiley Online Library Canada Nunavik Environmental Toxicology and Chemistry 33 11 2463 2471 |
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English |
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Abstract Mercury (Hg) has been detected in polar bear brain tissue, but its biological effects are not well known. Relationships between Hg concentrations and neurochemical enzyme activities and receptor binding were assessed in the cerebellum, frontal lobes, and occipital lobes of 24 polar bears collected from Nunavik (Northern Quebec), Canada. The concentration–response relationship was further studied with in vitro experiments using pooled brain homogenate of 12 randomly chosen bears. In environmentally exposed brain samples, there was no correlative relationship between Hg concentration and cholinesterase (ChE) activity or muscarinic acetylcholine receptor (mAChR) binding in any of the 3 brain regions. Monoamine oxidase (MAO) activity in the occipital lobe showed a negative correlative relationship with total Hg concentration. In vitro experiments, however, demonstrated that Hg (mercuric chloride and methylmercury chloride) can inhibit ChE and MAO activities and muscarinic mAChR binding. These results show that Hg can alter neurobiochemical parameters but the current environmental Hg exposure level does have an effect on the neurochemistry of polar bears from northern Canada. Environ Toxicol Chem 2014;33:2463–2471 . © 2014 SETAC |
author2 |
Natural Sciences and Engineering Research Council of Canada ArcticNet Canada Research Chairs |
format |
Article in Journal/Newspaper |
author |
Krey, Anke Kwan, Michael Chan, Hing Man |
spellingShingle |
Krey, Anke Kwan, Michael Chan, Hing Man In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
author_facet |
Krey, Anke Kwan, Michael Chan, Hing Man |
author_sort |
Krey, Anke |
title |
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
title_short |
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
title_full |
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
title_fullStr |
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
title_full_unstemmed |
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( Ursus maritimus) |
title_sort |
in vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears ( ursus maritimus) |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/etc.2685 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.2685 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.2685 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
Ursus maritimus Nunavik |
genre_facet |
Ursus maritimus Nunavik |
op_source |
Environmental Toxicology and Chemistry volume 33, issue 11, page 2463-2471 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/etc.2685 |
container_title |
Environmental Toxicology and Chemistry |
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33 |
container_issue |
11 |
container_start_page |
2463 |
op_container_end_page |
2471 |
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1800739942328958976 |