A model to resolve organochlorine pharmacokinetics in migrating humpback whales
Abstract Humpback whales are iconic mammals at the top of the Antarctic food chain. Their large reserves of lipid‐rich tissues such as blubber predispose them to accumulation of lipophilic contaminants throughout their lifetime. Changes in the volume and distribution of lipids in humpback whales, pa...
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crwiley:10.1002/etc.2603 2024-06-02T07:58:22+00:00 A model to resolve organochlorine pharmacokinetics in migrating humpback whales Cropp, Roger Nash, Susan Bengtson Hawker, Darryl Australian Research Council 2014 http://dx.doi.org/10.1002/etc.2603 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.2603 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.2603 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 33, issue 7, page 1638-1649 ISSN 0730-7268 1552-8618 journal-article 2014 crwiley https://doi.org/10.1002/etc.2603 2024-05-03T11:56:59Z Abstract Humpback whales are iconic mammals at the top of the Antarctic food chain. Their large reserves of lipid‐rich tissues such as blubber predispose them to accumulation of lipophilic contaminants throughout their lifetime. Changes in the volume and distribution of lipids in humpback whales, particularly during migration, could play an important role in the pharmacokinetics of lipophilic contaminants such as the organochlorine pesticide hexachlorobenzene (HCB). Previous models have examined constant feeding and nonmigratory scenarios. In the present study, the authors develop a novel heuristic model to investigate HCB dynamics in a humpback whale and its environment by coupling an ecosystem nutrient‐phytoplankton‐zooplankton‐detritus (NPZD) model, a dynamic energy budget (DEB) model, and a physiologically based pharmacokinetic (PBPK) model. The model takes into account the seasonal feeding pattern of whales, their energy requirements, and fluctuating contaminant burdens in the supporting plankton food chain. It is applied to a male whale from weaning to maturity, spanning 20 migration and feeding cycles. The model is initialized with environmental HCB burdens similar to those measured in the Southern Ocean and predicts blubber HCB concentrations consistent with empirical concentrations observed in a southern hemisphere population of male, migrating humpback whales. Results show for the first time some important details of the relationship between energy budgets and organochlorine pharmacokinetics. Environ Toxicol Chem 2014;33:1638–1649 . © 2014 SETAC Article in Journal/Newspaper Antarc* Antarctic Humpback Whale Southern Ocean Wiley Online Library Antarctic Southern Ocean The Antarctic Environmental Toxicology and Chemistry 33 7 1638 1649 |
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English |
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Abstract Humpback whales are iconic mammals at the top of the Antarctic food chain. Their large reserves of lipid‐rich tissues such as blubber predispose them to accumulation of lipophilic contaminants throughout their lifetime. Changes in the volume and distribution of lipids in humpback whales, particularly during migration, could play an important role in the pharmacokinetics of lipophilic contaminants such as the organochlorine pesticide hexachlorobenzene (HCB). Previous models have examined constant feeding and nonmigratory scenarios. In the present study, the authors develop a novel heuristic model to investigate HCB dynamics in a humpback whale and its environment by coupling an ecosystem nutrient‐phytoplankton‐zooplankton‐detritus (NPZD) model, a dynamic energy budget (DEB) model, and a physiologically based pharmacokinetic (PBPK) model. The model takes into account the seasonal feeding pattern of whales, their energy requirements, and fluctuating contaminant burdens in the supporting plankton food chain. It is applied to a male whale from weaning to maturity, spanning 20 migration and feeding cycles. The model is initialized with environmental HCB burdens similar to those measured in the Southern Ocean and predicts blubber HCB concentrations consistent with empirical concentrations observed in a southern hemisphere population of male, migrating humpback whales. Results show for the first time some important details of the relationship between energy budgets and organochlorine pharmacokinetics. Environ Toxicol Chem 2014;33:1638–1649 . © 2014 SETAC |
author2 |
Australian Research Council |
format |
Article in Journal/Newspaper |
author |
Cropp, Roger Nash, Susan Bengtson Hawker, Darryl |
spellingShingle |
Cropp, Roger Nash, Susan Bengtson Hawker, Darryl A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
author_facet |
Cropp, Roger Nash, Susan Bengtson Hawker, Darryl |
author_sort |
Cropp, Roger |
title |
A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
title_short |
A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
title_full |
A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
title_fullStr |
A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
title_full_unstemmed |
A model to resolve organochlorine pharmacokinetics in migrating humpback whales |
title_sort |
model to resolve organochlorine pharmacokinetics in migrating humpback whales |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/etc.2603 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.2603 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.2603 |
geographic |
Antarctic Southern Ocean The Antarctic |
geographic_facet |
Antarctic Southern Ocean The Antarctic |
genre |
Antarc* Antarctic Humpback Whale Southern Ocean |
genre_facet |
Antarc* Antarctic Humpback Whale Southern Ocean |
op_source |
Environmental Toxicology and Chemistry volume 33, issue 7, page 1638-1649 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/etc.2603 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
33 |
container_issue |
7 |
container_start_page |
1638 |
op_container_end_page |
1649 |
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1800741682414616576 |