Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance
Abstract Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders....
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crwiley:10.1002/ejp.1437 2024-06-02T08:15:21+00:00 Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Inge Landrø, Nils Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Nielsen, Christopher Sivert 2019 http://dx.doi.org/10.1002/ejp.1437 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejp.1437 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejp.1437 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejp.1437 en eng Wiley http://creativecommons.org/licenses/by/4.0/ European Journal of Pain volume 23, issue 9, page 1608-1618 ISSN 1090-3801 1532-2149 journal-article 2019 crwiley https://doi.org/10.1002/ejp.1437 2024-05-03T10:43:10Z Abstract Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. Methods This was a cross‐sectional study nested within the Tromsø‐6 survey. Neuropsychological test performance and the cold pressor test were investigated in 4,623 participants. Due to significant interaction with age, participants were divided into three age groups (<60, ≥60 to <70 and ≥70 years). Cox proportional hazard models assessed the relationship between neuropsychological tests and cold pressure pain tolerance, using hand‐withdrawal as event. The fully adjusted models controlled for sex, education, BMI, smoking status, exercise, systolic blood pressure, sleep problems and mental distress. Results In the adjusted models, participants aged ≥70 years showed a decreased hazard of hand withdrawal of 18% (HR 0.82, 95% CI (0.73, 0.92) per standard deviation on immediate verbal recall, and a decreased hazard of 23% (HR 0.77, 95% CI (0.65, 0.08) per standard deviation on psychomotor speed. Participants aged ≥60 to <70 years had a significant decreased hazard of 11% (HR 0.89, 95% CI (0.80, 0.98) per standard deviation on immediate word recall. In participants aged <60 years, there was a decreased hazard of 14% (HR 0.86 95% CI: 0.76, 0.98), per standard deviation on psychomotor speed. Conclusion Better performance on neuropsychological tests increased pain tolerance on the cold pressor test. These exposure effects were present in all age groups. Significance This paper describes substantial associations between cognitive functioning and cold pressor tolerance in 4,623 participants. Reduced psychomotor speed and poor verbal recall gave greater odds for hand‐withdrawal on the cold pressor task. The associations were stronger in older participants, indicating an interaction with age. Article in Journal/Newspaper Tromsø Wiley Online Library Tromsø European Journal of Pain 23 9 1608 1618 |
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Wiley Online Library |
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English |
description |
Abstract Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. Methods This was a cross‐sectional study nested within the Tromsø‐6 survey. Neuropsychological test performance and the cold pressor test were investigated in 4,623 participants. Due to significant interaction with age, participants were divided into three age groups (<60, ≥60 to <70 and ≥70 years). Cox proportional hazard models assessed the relationship between neuropsychological tests and cold pressure pain tolerance, using hand‐withdrawal as event. The fully adjusted models controlled for sex, education, BMI, smoking status, exercise, systolic blood pressure, sleep problems and mental distress. Results In the adjusted models, participants aged ≥70 years showed a decreased hazard of hand withdrawal of 18% (HR 0.82, 95% CI (0.73, 0.92) per standard deviation on immediate verbal recall, and a decreased hazard of 23% (HR 0.77, 95% CI (0.65, 0.08) per standard deviation on psychomotor speed. Participants aged ≥60 to <70 years had a significant decreased hazard of 11% (HR 0.89, 95% CI (0.80, 0.98) per standard deviation on immediate word recall. In participants aged <60 years, there was a decreased hazard of 14% (HR 0.86 95% CI: 0.76, 0.98), per standard deviation on psychomotor speed. Conclusion Better performance on neuropsychological tests increased pain tolerance on the cold pressor test. These exposure effects were present in all age groups. Significance This paper describes substantial associations between cognitive functioning and cold pressor tolerance in 4,623 participants. Reduced psychomotor speed and poor verbal recall gave greater odds for hand‐withdrawal on the cold pressor task. The associations were stronger in older participants, indicating an interaction with age. |
format |
Article in Journal/Newspaper |
author |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Inge Landrø, Nils Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Nielsen, Christopher Sivert |
spellingShingle |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Inge Landrø, Nils Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Nielsen, Christopher Sivert Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
author_facet |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Inge Landrø, Nils Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Nielsen, Christopher Sivert |
author_sort |
Jacobsen, Henrik Børsting |
title |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_short |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_full |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_fullStr |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_full_unstemmed |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_sort |
neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1002/ejp.1437 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejp.1437 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejp.1437 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejp.1437 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
European Journal of Pain volume 23, issue 9, page 1608-1618 ISSN 1090-3801 1532-2149 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1002/ejp.1437 |
container_title |
European Journal of Pain |
container_volume |
23 |
container_issue |
9 |
container_start_page |
1608 |
op_container_end_page |
1618 |
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1800739491024994304 |