Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application
Abstract Herein, we have established a dynamic double kinetic resolution (DDKR) strategy under the co‐catalysis of Raney nickel and Candida antarctica lipase B (CAL‐B) for the one‐pot simultaneous resolution of primary amines and secondary alcohols (or esters). The DDKR strategy was successfully app...
Published in: | European Journal of Organic Chemistry |
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Online Access: | http://dx.doi.org/10.1002/ejoc.201400042 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201400042 http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201400042/fullpdf |
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crwiley:10.1002/ejoc.201400042 2024-06-23T07:47:11+00:00 Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application Xia, Bo Cheng, Guilin Lin, Xianfu Wu, Qi 2014 http://dx.doi.org/10.1002/ejoc.201400042 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201400042 http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201400042/fullpdf en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Organic Chemistry volume 2014, issue 14, page 2917-2923 ISSN 1434-193X 1099-0690 journal-article 2014 crwiley https://doi.org/10.1002/ejoc.201400042 2024-06-11T04:41:51Z Abstract Herein, we have established a dynamic double kinetic resolution (DDKR) strategy under the co‐catalysis of Raney nickel and Candida antarctica lipase B (CAL‐B) for the one‐pot simultaneous resolution of primary amines and secondary alcohols (or esters). The DDKR strategy was successfully applied to the resolution of a series of racemic amines and secondary alcohols (or esters) as well as mexiletine, an important antiarrhythmic agent. The catalysts could be recycled and reused several times with the same high activity. Scale‐up experiments were also successful. As a more atom‐economical and efficient process than traditional simple kinetic resolutions, the DDKR strategy can be widely used to prepare optically pure amines and alcohols. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library European Journal of Organic Chemistry 2014 14 2917 2923 |
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crwiley |
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English |
description |
Abstract Herein, we have established a dynamic double kinetic resolution (DDKR) strategy under the co‐catalysis of Raney nickel and Candida antarctica lipase B (CAL‐B) for the one‐pot simultaneous resolution of primary amines and secondary alcohols (or esters). The DDKR strategy was successfully applied to the resolution of a series of racemic amines and secondary alcohols (or esters) as well as mexiletine, an important antiarrhythmic agent. The catalysts could be recycled and reused several times with the same high activity. Scale‐up experiments were also successful. As a more atom‐economical and efficient process than traditional simple kinetic resolutions, the DDKR strategy can be widely used to prepare optically pure amines and alcohols. |
format |
Article in Journal/Newspaper |
author |
Xia, Bo Cheng, Guilin Lin, Xianfu Wu, Qi |
spellingShingle |
Xia, Bo Cheng, Guilin Lin, Xianfu Wu, Qi Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
author_facet |
Xia, Bo Cheng, Guilin Lin, Xianfu Wu, Qi |
author_sort |
Xia, Bo |
title |
Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
title_short |
Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
title_full |
Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
title_fullStr |
Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
title_full_unstemmed |
Dynamic Double Kinetic Resolution of Amines and Alcohols under the Cocatalysis of Raney Nickel/ Candida antarctica Lipase B: From Concept to Application |
title_sort |
dynamic double kinetic resolution of amines and alcohols under the cocatalysis of raney nickel/ candida antarctica lipase b: from concept to application |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/ejoc.201400042 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201400042 http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201400042/fullpdf |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
European Journal of Organic Chemistry volume 2014, issue 14, page 2917-2923 ISSN 1434-193X 1099-0690 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ejoc.201400042 |
container_title |
European Journal of Organic Chemistry |
container_volume |
2014 |
container_issue |
14 |
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2917 |
op_container_end_page |
2923 |
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1802651280477257728 |