An Asymmetric, Chemo‐Enzymatic Synthesis of O ‐Acetylcyanohydrins

• Published in: European Journal of Organic Chemistry
• Main Authors: Belokon, Yuri N., Blacker, A. John, Clutterbuck, Lisa A., Hogg, David, North, Michael, Reeve, Christopher
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2006
• Subjects: Organic Chemistry; Physical and Theoretical Chemistry; Salen; Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1002/ejoc.200600467; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.200600467; https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.200600467

Abstract A one‐pot chemo‐enzymatic synthesis of highly enantiomerically enriched O ‐acetylcyanohydrins has been developed. The bimetallic (salen)titanium complex 1 is used to convert aldehydes into nonracemic ( R )‐ O ‐acetylcyanohydrins with 61 to 93 % enantiomeric excess. A lipase enzyme is then u...