Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats
Abstract Nobiletin (Nob) is reported to exhibit neuroprotective properties, which is limited by its low oral bioavailability. Antarctic krill oil (AKO) is abundant in n‐3 polyunsaturated fatty acids in the form of phospholipids, which exhibit an amphiphilic property. It is unclear whether AKO can en...
Published in: | European Journal of Lipid Science and Technology |
---|---|
Main Authors: | , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2022
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.202200049 |
id |
crwiley:10.1002/ejlt.202200049 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/ejlt.202200049 2024-03-17T08:54:26+00:00 Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats Kong, Jing‐Ya Wang, Cheng‐Cheng Duan, Xue‐Feng Shi, Hao‐Hao Xue, Chang‐Hu Wei, Zi‐Hao Huang, Qing‐Rong Zhang, Tian‐Tian Wang, Yu‐Ming National Natural Science Foundation of China 2022 http://dx.doi.org/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.202200049 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Lipid Science and Technology volume 124, issue 11 ISSN 1438-7697 1438-9312 Industrial and Manufacturing Engineering General Chemistry Food Science Biotechnology journal-article 2022 crwiley https://doi.org/10.1002/ejlt.202200049 2024-02-22T00:22:30Z Abstract Nobiletin (Nob) is reported to exhibit neuroprotective properties, which is limited by its low oral bioavailability. Antarctic krill oil (AKO) is abundant in n‐3 polyunsaturated fatty acids in the form of phospholipids, which exhibit an amphiphilic property. It is unclear whether AKO can enhance the bioavailability of nobiletin to facilitate the combined effect on neuroprotection. In the present study, the absorption of Nob carried by AKO is significantly enhanced in contrast to that suspended in corn oil. Moreover, Aβ 1–42 injected rats are utilized to clarify the effect of the combination of Nob and AKO on improving the memory and learning ability. Results present that the combination of AKO and Nob significantly reverses the cognitive and learning defects induced by Aβ 1–42 injection, but does not have ideal synergistic effect compared to AKO or Nob alone treated groups. Further molecular experiments imply that the neuroprotective effect may be attributed to the reduction of oxidative stress, the inhibition of apoptosis and tau phosphorylation, as well as the improvement of the neurotrophic activity. This study provides scientific insights and theoretical guidance for the nutritional interventions of the combined development of nobiletin and AKO to prevent neuropsychiatric disorders. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Wiley Online Library Antarctic European Journal of Lipid Science and Technology 124 11 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
topic |
Industrial and Manufacturing Engineering General Chemistry Food Science Biotechnology |
spellingShingle |
Industrial and Manufacturing Engineering General Chemistry Food Science Biotechnology Kong, Jing‐Ya Wang, Cheng‐Cheng Duan, Xue‐Feng Shi, Hao‐Hao Xue, Chang‐Hu Wei, Zi‐Hao Huang, Qing‐Rong Zhang, Tian‐Tian Wang, Yu‐Ming Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
topic_facet |
Industrial and Manufacturing Engineering General Chemistry Food Science Biotechnology |
description |
Abstract Nobiletin (Nob) is reported to exhibit neuroprotective properties, which is limited by its low oral bioavailability. Antarctic krill oil (AKO) is abundant in n‐3 polyunsaturated fatty acids in the form of phospholipids, which exhibit an amphiphilic property. It is unclear whether AKO can enhance the bioavailability of nobiletin to facilitate the combined effect on neuroprotection. In the present study, the absorption of Nob carried by AKO is significantly enhanced in contrast to that suspended in corn oil. Moreover, Aβ 1–42 injected rats are utilized to clarify the effect of the combination of Nob and AKO on improving the memory and learning ability. Results present that the combination of AKO and Nob significantly reverses the cognitive and learning defects induced by Aβ 1–42 injection, but does not have ideal synergistic effect compared to AKO or Nob alone treated groups. Further molecular experiments imply that the neuroprotective effect may be attributed to the reduction of oxidative stress, the inhibition of apoptosis and tau phosphorylation, as well as the improvement of the neurotrophic activity. This study provides scientific insights and theoretical guidance for the nutritional interventions of the combined development of nobiletin and AKO to prevent neuropsychiatric disorders. |
author2 |
National Natural Science Foundation of China |
format |
Article in Journal/Newspaper |
author |
Kong, Jing‐Ya Wang, Cheng‐Cheng Duan, Xue‐Feng Shi, Hao‐Hao Xue, Chang‐Hu Wei, Zi‐Hao Huang, Qing‐Rong Zhang, Tian‐Tian Wang, Yu‐Ming |
author_facet |
Kong, Jing‐Ya Wang, Cheng‐Cheng Duan, Xue‐Feng Shi, Hao‐Hao Xue, Chang‐Hu Wei, Zi‐Hao Huang, Qing‐Rong Zhang, Tian‐Tian Wang, Yu‐Ming |
author_sort |
Kong, Jing‐Ya |
title |
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
title_short |
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
title_full |
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
title_fullStr |
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
title_full_unstemmed |
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ 1–42 Induced Rats |
title_sort |
dietary antarctic krill oil enhances the oral bioavailability of nobiletin but has no ideal synergistic effect on improving memory and cognition ability in aβ 1–42 induced rats |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.202200049 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.202200049 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
European Journal of Lipid Science and Technology volume 124, issue 11 ISSN 1438-7697 1438-9312 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ejlt.202200049 |
container_title |
European Journal of Lipid Science and Technology |
container_volume |
124 |
container_issue |
11 |
_version_ |
1793772673270022144 |