Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors
In this study, ten policosanyl phenolates were synthesized via a two‐step chemoenzymatic route. The intermediate vinyl esters were first chemically produced and subsequently esterified with policosanols catalyzed by Novozyme 435 ( Candida antarctica lipase B). The conversion yields of the policosany...
Published in: | European Journal of Lipid Science and Technology |
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crwiley:10.1002/ejlt.201400296 2024-09-15T17:45:45+00:00 Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors Wang, Zhiqiang Hwang, Seung Hwan Lim, Soon Sung National Research Foundation of Korea National Research Foundation of Korea Hallym University Research Fund 2014 http://dx.doi.org/10.1002/ejlt.201400296 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejlt.201400296 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.201400296 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.201400296 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Lipid Science and Technology volume 117, issue 3, page 300-310 ISSN 1438-7697 1438-9312 journal-article 2014 crwiley https://doi.org/10.1002/ejlt.201400296 2024-07-18T04:22:50Z In this study, ten policosanyl phenolates were synthesized via a two‐step chemoenzymatic route. The intermediate vinyl esters were first chemically produced and subsequently esterified with policosanols catalyzed by Novozyme 435 ( Candida antarctica lipase B). The conversion yields of the policosanyl phenolates were in the range of 4.20–37.14%. Their antioxidant activities were evaluated. Results showed that, compared with the corresponding phenolic acids, all synthesized policosanyl phenolates had better activities for peroxide value, but worse for 2,2'‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) assay; policosanyl p ‐coumarate and policosanyl 5‐phenylvalerate showed a moderate and durable inhibition effect on lipid oxidation both in a linoleic acid system and a cooked pork system. Practical applications: It is important to develop antioxidants from natural sources. The lipophilization of phenolic acids with fatty alcohols can improve the hydrophobicity and change the antioxidant capacity of phenols. This study focuses on policosanol, which is a food‐grade mixture of long‐chain aliphatic primary alcohols, having development and application potential as a cost‐effective food additive. According to our results, policosanyl phenolates, which are a new range of amphiphilic antioxidant molecules, have the potential for use as alternative food antioxidants in the food industry. The policosanyl phenolates were synthesized via a two‐step route as shown in the figure. The intermediate vinyl esters were first chemically produced and subsequently esterified with policosanols catalyzed by Novozyme 435 ( Candida antarctica lipase B). Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library European Journal of Lipid Science and Technology 117 3 300 310 |
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English |
description |
In this study, ten policosanyl phenolates were synthesized via a two‐step chemoenzymatic route. The intermediate vinyl esters were first chemically produced and subsequently esterified with policosanols catalyzed by Novozyme 435 ( Candida antarctica lipase B). The conversion yields of the policosanyl phenolates were in the range of 4.20–37.14%. Their antioxidant activities were evaluated. Results showed that, compared with the corresponding phenolic acids, all synthesized policosanyl phenolates had better activities for peroxide value, but worse for 2,2'‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) assay; policosanyl p ‐coumarate and policosanyl 5‐phenylvalerate showed a moderate and durable inhibition effect on lipid oxidation both in a linoleic acid system and a cooked pork system. Practical applications: It is important to develop antioxidants from natural sources. The lipophilization of phenolic acids with fatty alcohols can improve the hydrophobicity and change the antioxidant capacity of phenols. This study focuses on policosanol, which is a food‐grade mixture of long‐chain aliphatic primary alcohols, having development and application potential as a cost‐effective food additive. According to our results, policosanyl phenolates, which are a new range of amphiphilic antioxidant molecules, have the potential for use as alternative food antioxidants in the food industry. The policosanyl phenolates were synthesized via a two‐step route as shown in the figure. The intermediate vinyl esters were first chemically produced and subsequently esterified with policosanols catalyzed by Novozyme 435 ( Candida antarctica lipase B). |
author2 |
National Research Foundation of Korea National Research Foundation of Korea Hallym University Research Fund |
format |
Article in Journal/Newspaper |
author |
Wang, Zhiqiang Hwang, Seung Hwan Lim, Soon Sung |
spellingShingle |
Wang, Zhiqiang Hwang, Seung Hwan Lim, Soon Sung Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
author_facet |
Wang, Zhiqiang Hwang, Seung Hwan Lim, Soon Sung |
author_sort |
Wang, Zhiqiang |
title |
Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
title_short |
Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
title_full |
Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
title_fullStr |
Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
title_full_unstemmed |
Chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
title_sort |
chemoenzymatically synthesized policosanyl phenolates as autoxidation inhibitors |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/ejlt.201400296 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejlt.201400296 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.201400296 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.201400296 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
European Journal of Lipid Science and Technology volume 117, issue 3, page 300-310 ISSN 1438-7697 1438-9312 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ejlt.201400296 |
container_title |
European Journal of Lipid Science and Technology |
container_volume |
117 |
container_issue |
3 |
container_start_page |
300 |
op_container_end_page |
310 |
_version_ |
1810493655375413248 |