Generation of antigen‐specific CD4 + T cell lines from naive precursors

• Published in: European Journal of Immunology
• Main Authors: Mehta‐Damani, Anita, Markowicz, Sergiusz, Engleman, Edgar G.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1995
• Subjects: Keyhole; Sperm whale
• Online Access: http://dx.doi.org/10.1002/eji.1830250511; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.1830250511; https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.1830250511

Abstract The conditions required for sensitizing naive T cells to nominal antigen are poorly understood. In this report we describe an in vitro system for generating antigen‐specific CD4 + T cells from previously unprimed individuals. Freshly isolated CD4 + T cells were cultured with keyhole limpet...