Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories
Abstract Small populations are likely to have a low genetic ability for disease resistance due to loss of genetic variation through inbreeding and genetic drift. In vertebrates, the highest genetic diversity of the immune system is located at genes within the major histocompatibility complex (MHC)....
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crwiley:10.1002/ece3.13 2024-06-02T07:54:41+00:00 Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories Borg, Åsa Alexandra Pedersen, Sindre Andre Jensen, Henrik Westerdahl, Helena 2011 http://dx.doi.org/10.1002/ece3.13 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fece3.13 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ece3.13 en eng Wiley http://creativecommons.org/licenses/by-nc/3.0/ Ecology and Evolution volume 1, issue 2, page 145-159 ISSN 2045-7758 2045-7758 journal-article 2011 crwiley https://doi.org/10.1002/ece3.13 2024-05-03T10:50:02Z Abstract Small populations are likely to have a low genetic ability for disease resistance due to loss of genetic variation through inbreeding and genetic drift. In vertebrates, the highest genetic diversity of the immune system is located at genes within the major histocompatibility complex (MHC). Interestingly, parasite‐mediated selection is thought to potentially maintain variation at MHC loci even in populations that are monomorphic at other loci. Therefore, general loss of genetic variation in the genome may not necessarily be associated with low variation at MHC loci. We evaluated inter‐ and intrapopulation variation in MHC genotypes between an inbred (Aldra) and a relatively outbred population (Hestmannøy) of house sparrows ( Passer domesticus ) in a metapopulation at Helgeland, Norway. Genomic (gDNA) and transcribed (cDNA) alleles of functional MHC class I and IIB loci, along with neutral noncoding microsatellite markers, were analyzed to obtain relevant estimates of genetic variation. We found lower allelic richness in microsatellites in the inbred population, but high genetic variation in MHC class I and IIB loci in both populations. This suggests that also the inbred population could be under balancing selection to maintain genetic variation for pathogen resistance. Article in Journal/Newspaper Aldra Helgeland Wiley Online Library Aldra ENVELOPE(13.100,13.100,66.400,66.400) Helgeland Norway Ecology and Evolution 1 2 145 159 |
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Wiley Online Library |
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English |
description |
Abstract Small populations are likely to have a low genetic ability for disease resistance due to loss of genetic variation through inbreeding and genetic drift. In vertebrates, the highest genetic diversity of the immune system is located at genes within the major histocompatibility complex (MHC). Interestingly, parasite‐mediated selection is thought to potentially maintain variation at MHC loci even in populations that are monomorphic at other loci. Therefore, general loss of genetic variation in the genome may not necessarily be associated with low variation at MHC loci. We evaluated inter‐ and intrapopulation variation in MHC genotypes between an inbred (Aldra) and a relatively outbred population (Hestmannøy) of house sparrows ( Passer domesticus ) in a metapopulation at Helgeland, Norway. Genomic (gDNA) and transcribed (cDNA) alleles of functional MHC class I and IIB loci, along with neutral noncoding microsatellite markers, were analyzed to obtain relevant estimates of genetic variation. We found lower allelic richness in microsatellites in the inbred population, but high genetic variation in MHC class I and IIB loci in both populations. This suggests that also the inbred population could be under balancing selection to maintain genetic variation for pathogen resistance. |
format |
Article in Journal/Newspaper |
author |
Borg, Åsa Alexandra Pedersen, Sindre Andre Jensen, Henrik Westerdahl, Helena |
spellingShingle |
Borg, Åsa Alexandra Pedersen, Sindre Andre Jensen, Henrik Westerdahl, Helena Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
author_facet |
Borg, Åsa Alexandra Pedersen, Sindre Andre Jensen, Henrik Westerdahl, Helena |
author_sort |
Borg, Åsa Alexandra |
title |
Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
title_short |
Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
title_full |
Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
title_fullStr |
Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
title_full_unstemmed |
Variation in MHC genotypes in two populations of house sparrow ( Passer domesticus) with different population histories |
title_sort |
variation in mhc genotypes in two populations of house sparrow ( passer domesticus) with different population histories |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1002/ece3.13 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fece3.13 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ece3.13 |
long_lat |
ENVELOPE(13.100,13.100,66.400,66.400) |
geographic |
Aldra Helgeland Norway |
geographic_facet |
Aldra Helgeland Norway |
genre |
Aldra Helgeland |
genre_facet |
Aldra Helgeland |
op_source |
Ecology and Evolution volume 1, issue 2, page 145-159 ISSN 2045-7758 2045-7758 |
op_rights |
http://creativecommons.org/licenses/by-nc/3.0/ |
op_doi |
https://doi.org/10.1002/ece3.13 |
container_title |
Ecology and Evolution |
container_volume |
1 |
container_issue |
2 |
container_start_page |
145 |
op_container_end_page |
159 |
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1800742970804142080 |