Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool
Abstract Somitic β‐catenin is involved in both maintaining a stem cell population and controlling myogenic differentiation. It is unclear how β‐catenin‐dependent Wnt signaling accomplishes these disparate roles. The present study shows that only dorsal cells in the early somite respond to β‐catenin‐...
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Online Access: | http://dx.doi.org/10.1002/dvdy.22098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.22098 http://onlinelibrary.wiley.com/wol1/doi/10.1002/dvdy.22098/fullpdf |
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crwiley:10.1002/dvdy.22098 2024-06-02T08:05:47+00:00 Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool Brauner, Ian Spicer, Douglas B. Krull, Catherine E. Venuti, Judith M. 2009 http://dx.doi.org/10.1002/dvdy.22098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.22098 http://onlinelibrary.wiley.com/wol1/doi/10.1002/dvdy.22098/fullpdf en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Developmental Dynamics volume 239, issue 1, page 222-236 ISSN 1058-8388 1097-0177 journal-article 2009 crwiley https://doi.org/10.1002/dvdy.22098 2024-05-06T07:04:30Z Abstract Somitic β‐catenin is involved in both maintaining a stem cell population and controlling myogenic differentiation. It is unclear how β‐catenin‐dependent Wnt signaling accomplishes these disparate roles. The present study shows that only dorsal cells in the early somite respond to β‐catenin‐dependent Wnt signaling and as the somites compartmentalize to form the dermomyotome and myotome, responding cells are detected primarily in the dorsomedial lip (DML). Forced activation of Wnt target genes in DML cells prevents their progeny from entering the myotome, while blocking activation allows myotomal entry. This suggests a role for β‐catenin‐dependent/Wnt signaling in maintaining progenitor cells in the DML and that if β‐catenin‐dependent/Wnt signaling is required to induce myogenesis, the response is transitory and rapidly down‐regulated. Developmental Dynamics 239:222–236, 2010. © 2009 Wiley‐Liss, Inc. Article in Journal/Newspaper DML Wiley Online Library Developmental Dynamics NA NA |
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Abstract Somitic β‐catenin is involved in both maintaining a stem cell population and controlling myogenic differentiation. It is unclear how β‐catenin‐dependent Wnt signaling accomplishes these disparate roles. The present study shows that only dorsal cells in the early somite respond to β‐catenin‐dependent Wnt signaling and as the somites compartmentalize to form the dermomyotome and myotome, responding cells are detected primarily in the dorsomedial lip (DML). Forced activation of Wnt target genes in DML cells prevents their progeny from entering the myotome, while blocking activation allows myotomal entry. This suggests a role for β‐catenin‐dependent/Wnt signaling in maintaining progenitor cells in the DML and that if β‐catenin‐dependent/Wnt signaling is required to induce myogenesis, the response is transitory and rapidly down‐regulated. Developmental Dynamics 239:222–236, 2010. © 2009 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Brauner, Ian Spicer, Douglas B. Krull, Catherine E. Venuti, Judith M. |
spellingShingle |
Brauner, Ian Spicer, Douglas B. Krull, Catherine E. Venuti, Judith M. Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
author_facet |
Brauner, Ian Spicer, Douglas B. Krull, Catherine E. Venuti, Judith M. |
author_sort |
Brauner, Ian |
title |
Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
title_short |
Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
title_full |
Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
title_fullStr |
Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
title_full_unstemmed |
Identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent Wnt signaling in maintaining the DML myogenic progenitor pool |
title_sort |
identification of responsive cells in the developing somite supports a role for β‐catenin‐dependent wnt signaling in maintaining the dml myogenic progenitor pool |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1002/dvdy.22098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.22098 http://onlinelibrary.wiley.com/wol1/doi/10.1002/dvdy.22098/fullpdf |
genre |
DML |
genre_facet |
DML |
op_source |
Developmental Dynamics volume 239, issue 1, page 222-236 ISSN 1058-8388 1097-0177 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/dvdy.22098 |
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Developmental Dynamics |
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1800750661387681792 |