Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon
Abstract Leptin and ghrelin are known to regulate energy homeostasis via hypothalamic neuropeptide signaling in mammals. Recent studies have discovered that these hormones exist in teleosts, however, very little is known concerning their role during teleost ontogeny. Here, we have examined the stead...
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crwiley:10.1002/dneu.20803 2024-06-23T07:51:16+00:00 Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon Moen, Anne‐Grethe Gamst Murashita, Koji Finn, Roderick Nigel 2010 http://dx.doi.org/10.1002/dneu.20803 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdneu.20803 https://onlinelibrary.wiley.com/doi/pdf/10.1002/dneu.20803 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Developmental Neurobiology volume 70, issue 9, page 649-658 ISSN 1932-8451 1932-846X journal-article 2010 crwiley https://doi.org/10.1002/dneu.20803 2024-06-11T04:37:53Z Abstract Leptin and ghrelin are known to regulate energy homeostasis via hypothalamic neuropeptide signaling in mammals. Recent studies have discovered that these hormones exist in teleosts, however, very little is known concerning their role during teleost ontogeny. Here, we have examined the steady state levels of leptins, ghrelins, their target neuropetides and several growth factors during Atlantic salmon development. Initial experiments revealed differential expression of leptin genes and ghrelin isoforms during embryogenesis. In larvae, equal upregulation of ghrl1 and ghrl2 was observed just prior to exogenous feeding while a surge of lepa1 occurred one week after first‐feeding. Subsequent dissection of the embryos and larvae showed that lepa1 , cart , pomca1, and agrp are supplied as maternal transcripts. The earliest zygotic expression was observed for lepa1 and cart at 320 day degrees. By 400 day degrees, this expression was localized to the head and coincided with upregulation of ghrl2 and npy . Over the hatching period growth factor signaling predominated. The ghrelin surge prior to first‐feeding was exclusively localized in the internal organs and coincided with upregulation of npy and agrp in the head and agrp in the trunk. One week after exogenous feeding was established major peaks were detected in the head for lepa1 and pomca1 with increasing levels of cart , while lepa1 was also significantly expressed in the trunk. By integrating theses data into an ontogenetic model, we suggest that the mediation of Atlantic salmon energy homeostatic pathways via endocrine and neuropeptide signaling retains putative features of the mammalian system. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 649–658, 2010 Article in Journal/Newspaper Atlantic salmon Wiley Online Library Developmental Neurobiology n/a n/a |
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English |
description |
Abstract Leptin and ghrelin are known to regulate energy homeostasis via hypothalamic neuropeptide signaling in mammals. Recent studies have discovered that these hormones exist in teleosts, however, very little is known concerning their role during teleost ontogeny. Here, we have examined the steady state levels of leptins, ghrelins, their target neuropetides and several growth factors during Atlantic salmon development. Initial experiments revealed differential expression of leptin genes and ghrelin isoforms during embryogenesis. In larvae, equal upregulation of ghrl1 and ghrl2 was observed just prior to exogenous feeding while a surge of lepa1 occurred one week after first‐feeding. Subsequent dissection of the embryos and larvae showed that lepa1 , cart , pomca1, and agrp are supplied as maternal transcripts. The earliest zygotic expression was observed for lepa1 and cart at 320 day degrees. By 400 day degrees, this expression was localized to the head and coincided with upregulation of ghrl2 and npy . Over the hatching period growth factor signaling predominated. The ghrelin surge prior to first‐feeding was exclusively localized in the internal organs and coincided with upregulation of npy and agrp in the head and agrp in the trunk. One week after exogenous feeding was established major peaks were detected in the head for lepa1 and pomca1 with increasing levels of cart , while lepa1 was also significantly expressed in the trunk. By integrating theses data into an ontogenetic model, we suggest that the mediation of Atlantic salmon energy homeostatic pathways via endocrine and neuropeptide signaling retains putative features of the mammalian system. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 649–658, 2010 |
format |
Article in Journal/Newspaper |
author |
Moen, Anne‐Grethe Gamst Murashita, Koji Finn, Roderick Nigel |
spellingShingle |
Moen, Anne‐Grethe Gamst Murashita, Koji Finn, Roderick Nigel Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
author_facet |
Moen, Anne‐Grethe Gamst Murashita, Koji Finn, Roderick Nigel |
author_sort |
Moen, Anne‐Grethe Gamst |
title |
Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
title_short |
Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
title_full |
Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
title_fullStr |
Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
title_full_unstemmed |
Ontogeny of energy homeostatic pathways via neuroendocrine signaling in Atlantic salmon |
title_sort |
ontogeny of energy homeostatic pathways via neuroendocrine signaling in atlantic salmon |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1002/dneu.20803 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdneu.20803 https://onlinelibrary.wiley.com/doi/pdf/10.1002/dneu.20803 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Developmental Neurobiology volume 70, issue 9, page 649-658 ISSN 1932-8451 1932-846X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/dneu.20803 |
container_title |
Developmental Neurobiology |
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_version_ |
1802642304554500096 |