Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid
Abstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E ( APOE ) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (...
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crwiley:10.1002/dad2.12136 2024-06-02T08:12:45+00:00 Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey‐Smith, Stephanie R. Ames, David Masters, Colin L Maruff, Paul 2021 http://dx.doi.org/10.1002/dad2.12136 https://onlinelibrary.wiley.com/doi/pdf/10.1002/dad2.12136 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dad2.12136 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring volume 13, issue 1 ISSN 2352-8729 2352-8729 journal-article 2021 crwiley https://doi.org/10.1002/dad2.12136 2024-05-03T10:47:37Z Abstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E ( APOE ) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT) over 6 days. Results Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non‐carriers (d = 0.3). Rates of learning on the ORCA‐LLT were significantly slower in Aβ– ε4 carriers compared to non‐carriers (d = 1.2). Discussion In Aβ– CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA‐LLT. Alzheimer's disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds. Article in Journal/Newspaper Orca Wiley Online Library Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 13 1 |
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Abstract Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E ( APOE ) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT) over 6 days. Results Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non‐carriers (d = 0.3). Rates of learning on the ORCA‐LLT were significantly slower in Aβ– ε4 carriers compared to non‐carriers (d = 1.2). Discussion In Aβ– CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA‐LLT. Alzheimer's disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds. |
format |
Article in Journal/Newspaper |
author |
Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey‐Smith, Stephanie R. Ames, David Masters, Colin L Maruff, Paul |
spellingShingle |
Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey‐Smith, Stephanie R. Ames, David Masters, Colin L Maruff, Paul Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
author_facet |
Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey‐Smith, Stephanie R. Ames, David Masters, Colin L Maruff, Paul |
author_sort |
Lim, Yen Ying |
title |
Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
title_short |
Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
title_full |
Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
title_fullStr |
Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
title_full_unstemmed |
Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid |
title_sort |
learning deficit in cognitively normal apoe ε4 carriers with low β‐amyloid |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1002/dad2.12136 https://onlinelibrary.wiley.com/doi/pdf/10.1002/dad2.12136 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dad2.12136 |
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Orca |
genre_facet |
Orca |
op_source |
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring volume 13, issue 1 ISSN 2352-8729 2352-8729 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1002/dad2.12136 |
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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
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13 |
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